Two New Sesquiterpenoids Isolated From Cyperus rotundus L

Two new sesquiterpenoids, isocyperotundone (1) and 1,4-epoxy-4-hydroxy-4,5-seco-guain-11-en-5-one (2), together with 6 known sesquiterpenoids, cyperotundone (3), cyperenoic acid (4), sugetriol triacetate (5), cyperusol A(3) (6), cyperusol A(2) (7), and cyperusol A(1) (8), were isolated from the methanol extract of the rhizomes of Cyperus rotundus L. High-resolution electrospray ionization mass spectrometry and 1-dimensional (1D) and 2D nuclear magnetic resonance spectroscopy were used to establish the structures of all the compounds. All the compounds were tested for activity on nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) signaling. Compounds 1-7 exhibited inhibitory activity on tumor necrosis factor-a-induced activation of the NF-kappa B pathway, with half-maximal inhibitory concentration values ranging from 34.5 to 73.7 mu mol/L.

Automated summary

Two new sesquiterpenoids, along with 6 known sesquiterpenoids, were isolated from the rhizomes of Cyperus rotundus L. All compounds were structurally elucidated and tested for their inhibitory activity on the NF-κB signaling pathway, with 7 compounds showing varying degrees of inhibition.