Journal
NANOMEDICINE
Volume 16, Issue 5, Pages 401-414Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2020-0403
Keywords
anti-inflammatory efficacy; factorial design; ketorolac tromethamine; nanoparticles; ocular administration
Funding
- Spanish Ministry of Science and Innovation [MAT201459134R]
Ask authors/readers for more resources
The optimized KT-NPs with small particle size and high encapsulation efficiency showed superior release and retention in the eye compared to the commercial reference, without causing eye irritation. Therefore, KT-NPs are a suitable alternative for the treatment of eye inflammatory diseases.
Aim: The development and optimization of Ketorolac tromethamine-loaded polylactic-co-glycolic acid nanoparticles (KT-NPs) for the treatment of inflammatory processes of the eye. Materials & methods: KT-NPs were developed by factorial design and characterized by assessing their physicochemical properties. Biopharmaceutical behavior studies, ocular tolerance, anti-inflammatory efficacy and bioavailability tests were performed on pigs. Results: Optimized KT-NPs of 112 nm, narrow distribution with encapsulation efficiency near 100% were obtained. KT release followed the Weibull model and there was significantly greater retention in the cornea and sclera than in the commercial reference. KT-NPs showed no signs of ocular irritancy and similar anti-inflammatory efficacy to the commercial reference. Conclusion: KT-NPs were a suitable alternative for the treatment of inflammatory disorders of the anterior and posterior segments of the eye as an alternative to conventional topical formulations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available