Chiral Recognition for Chromatography and Membrane-Based Separations: Recent Developments and Future Prospects

With the rapid development of global industry and increasingly frequent product circulation, the separation and detection of chiral drugs/pesticides are becoming increasingly important. The chiral nature of substances can result in harm to the human body, and the selective endocrine-disrupting effect of drug enantiomers is caused by differential enantiospecific binding to receptors. This review is devoted to the specific recognition and resolution of chiral molecules by chromatography and membrane-based enantioseparation techniques. Chromatographic enantiomer separations with chiral stationary phase (CSP)-based columns and membrane-based enantiomer filtration are detailed. In addition, the unique properties of these chiral resolution methods have been summarized for practical applications in the chemistry, environment, biology, medicine, and food industries. We further discussed the recognition mechanism in analytical enantioseparations and analyzed recent developments and future prospects of chromatographic and membrane-based enantioseparations.

Automated summary

With the rapid development of global industry and increasing product circulation, the separation and detection of chiral drugs/pesticides are becoming increasingly important due to their potential harm to the human body. Chromatography and membrane-based enantioseparation techniques play a vital role in specific recognition and resolution of chiral molecules, with wide practical applications in various industries. Recent advancements and future prospects in chromatographic and membrane-based enantioseparations have been discussed, highlighting their unique properties for selective separation and identification of chiral substances.