Journal
MOLECULES
Volume 26, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/molecules26030711
Keywords
COVID-19; SARS-CoV-2; PUFA; molecular docking; spike protein; DHA
Funding
- Universidad La Salle-Mexico through the COVID-19 challenge initiative [ID41, ID34]
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Countries with high PUFA intake have lower incidence and higher recovery rates of COVID-19. Both linoleic acid and omega-3 PUFA can stabilize the closed conformation of spike protein, potentially reducing viral entrance to cells and COVID-19 complications.
SARS-CoV-2 infects host cells by interacting its spike protein with surface angiotensin-converting enzyme 2 (ACE2) receptors, expressed in lung and other cell types. Although several risk factors could explain why some countries have lower incidence and fatality rates than others, environmental factors such as diet should be considered. It has been described that countries with high polyunsaturated fatty acid (PUFA) intake have a lower number of COVID-19 victims and a higher rate of recovery from the disease. Moreover, it was found that linoleic acid, an omega-6 PUFA, could stabilize the spike protein in a closed conformation, blocking its interaction with ACE2. These facts prompted us to perform in silico simulations to determine if other PUFA could also stabilize the closed conformation of spike protein and potentially lead to a reduction in SARS-CoV-2 infection. We found that: (a) countries whose source of omega-3 is from marine origin have lower fatality rates; and (b) like linoleic acid, omega-3 PUFA could also bind to the closed conformation of spike protein and therefore, could help reduce COVID-19 complications by reducing viral entrance to cells, in addition to their known anti-inflammatory effects.
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