Mealworm Oil (MWO) Enhances Wound Healing Potential through the Activation of Fibroblast and Endothelial Cells

Mealworm and mealworm oil (MWO) have been reported to affect antioxidant, anti-coagulation, anti-adipogenic and anti-inflammatory activities. However, the function of MWO in wound healing is still unclear. In this study, we found that MWO induced the migration of fibroblast cells and mRNA expressions of wound healing factors such as alpha-smooth muscle actin (alpha-SMA), collagen-1 (COL-1) and vascular endothelial growth factor (VEGF) in fibroblast cells. The tube formation and migration of endothelial cells were promoted through the activation of VEGF/VEGF receptor-2 (VEGFR-2)-mediated downstream signals including AKT, extracellular signal-regulated kinase (ERK) and p38 by MWO-stimulated fibroblasts for angiogenesis. Moreover, we confirmed that MWO promoted skin wound repair by collagen synthesis, re-epithelialization and angiogenesis in an in vivo excisional wound model. These results demonstrate that MWO might have potential as a therapeutic agent for the treatment of skin wounds.

Automated summary

Mealworm and mealworm oil have been reported to have effects on antioxidant, anti-coagulation, anti-adipogenic, and anti-inflammatory activities. This study demonstrates that mealworm oil may promote wound healing by inducing fibroblast migration and expression of wound healing factors, as well as promoting endothelial cell tube formation and migration through VEGF/VEGFR-2-mediated signaling pathways. These findings suggest that mealworm oil could be a potential therapeutic agent for skin wound treatment.