Journal
MOLECULES
Volume 26, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/molecules26041080
Keywords
Arctic; fungi; cylindromicin; tyrosinase
Funding
- National Key Research & Development Program of China [2018YFC1406705, 2018YFC1406704]
- National Natural Science Foundation of China (NSFC) [81872778, 41406183]
- Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML 2019ZD0406]
- UCAS Scholarship for International Students
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A fungus strain Tolypocladium cylindrosporum was isolated from an Arctic-derived glacier sediment sample, producing a new compound cylindromicin and seven known secondary metabolites. The chemical structures of these compounds were determined through comprehensive spectroscopic analyses. Cylindromicin exhibited significant tyrosinase inhibition activity, showcasing Polar fungi as a potential source for new bioactive natural products.
The fungus strain SCSIO 40433 was isolated from an Arctic-derived glacier sediment sample and characterized as Tolypocladium cylindrosporum. A new compound, cylindromicin (1), and seven known secondary metabolites (2-8) were isolated from this strain. The chemical structures of these compounds were elucidated by comprehensive spectroscopic analyses. Cylindromicin (1) featured a 3,4-dihydro-2H-pyran skeleton. The absolute configuration of compound 1 was assigned via interpretation of key Nuclear Overhauser Effect Spectroscopy (NOESY) correlations and Electronic Circular Dichroism (ECD) calculation. Cylindromicin (1) exhibited significant tyrosinase inhibition activity. This study highlights Polar fungi as a potential resource for new bioactive natural products.
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