Related references
Note: Only part of the references are listed.Targeting the DNA damage response (DDR) by natural compounds
Jana van Stuijvenberg et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2020)
New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens
Sherif S. Ebada et al.
MARINE DRUGS (2019)
The Emerging Ecological and Biogeochemical Importance of Sponges on Coral Reefs
Joseph R. Pawlik et al.
Annual Review of Marine Science (2019)
Novel meriolin derivatives as rapid apoptosis inducers
Daniel Driessen et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2019)
First Results from a Screening of 300 Naturally Occurring Compounds: 4,6-dibromo-2-(2′,4′-dibromophenoxy)phenol, 4,5,6-tribromo-2-(2′,4′-dibromophenoxy)phenol, and 5-epi-nakijinone Q as Substances with the Potential for Anticancer Therapy
Saskia Mayer et al.
MARINE DRUGS (2019)
Brominated Diphenyl Ethers Including a New Tribromoiododiphenyl Ether from the Vietnamese Marine Sponge Arenosclera sp. and Their Antibacterial Activities
Dae-Won Ki et al.
CHEMISTRY & BIODIVERSITY (2019)
Sponge-derived polybrominated diphenyl ethers and dibenzo-p-dioxins, irreversible inhibitors of the bacterial α-d-galactosidase
Natalia K. Utkina et al.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS (2019)
The role of natural products in modern drug discovery
Joao R. Calixto
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS (2019)
Marine Invertebrate Natural Products that Target Microtubules
John H. Miller et al.
JOURNAL OF NATURAL PRODUCTS (2018)
The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane
Philip Boehler et al.
CELL DEATH & DISEASE (2018)
The caspase-activated DNase: apoptosis and beyond
Brian D. Larsen et al.
FEBS JOURNAL (2017)
Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II
Masayoshi Arai et al.
JOURNAL OF NATURAL MEDICINES (2017)
Marine Sponge Natural Products with Anticancer Potential: An Updated Review
Cinzia Calcabrini et al.
MARINE DRUGS (2017)
Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases
Nadege Loaec et al.
MARINE DRUGS (2017)
Marine natural products
John W. Blunt et al.
NATURAL PRODUCT REPORTS (2017)
Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges
Vinayak Agarwal et al.
NATURE CHEMICAL BIOLOGY (2017)
Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges
Gerald Lackner et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Targeting anti-apoptotic BCL2 family proteins in haematological malignancies - from pathogenesis to treatment
Meike Vogler et al.
BRITISH JOURNAL OF HAEMATOLOGY (2017)
Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse
Vinayak Agarwal et al.
CHEMICAL REVIEWS (2017)
Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity
Hongbing Liu et al.
JOURNAL OF NATURAL PRODUCTS (2016)
Natural Products as Sources of New Drugs from 1981 to 2014
David J. Newman et al.
JOURNAL OF NATURAL PRODUCTS (2016)
Polybrominated diphenyl ethers with potent and broad spectrum antimicrobial activity from the marine sponge Dysidea
Shi Sun et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Complexity of Naturally Produced Polybrominated Diphenyl Ethers Revealed via Mass Spectrometry
Vinayak Agarwal et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2015)
Identification of Antiviral Agents Targeting Hepatitis B Virus Promoter from Extracts of Indonesian Marine Organisms by a Novel Cell-Based Screening Assay
Atsuya Yamashita et al.
MARINE DRUGS (2015)
Enzymatic Synthesis of Polybrominated Dioxins from the Marine Environment
Vinayak Agarwal et al.
ACS CHEMICAL BIOLOGY (2014)
PBDE: Structure-Activity Studies for the Inhibition of Hepatitis C Virus NS3 Helicase
Kazi Abdus Salam et al.
MOLECULES (2014)
Marine Microorganism-Invertebrate Assemblages: Perspectives to Solve the Supply Problem in the Initial Steps of Drug Discovery
Miguel Costa Leal et al.
MARINE DRUGS (2014)
Biosynthesis of polybrominated aromatic organic compounds by marine bacteria
Vinayak Agarwal et al.
NATURE CHEMICAL BIOLOGY (2014)
Biotransformation of BDE-47 to Potentially Toxic Metabolites Is Predominantly Mediated by Human CYP2B6
Maria Luisa Feo et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2013)
Assessment of the Binding of Hydroxylated Polybrominated Diphenyl Ethers to Thyroid Hormone Transport Proteins Using a Site-Specific Fluorescence Probe
Xiao M. Ren et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2012)
Horny sponges and their affairs: On the phylogenetic relationships of keratose sponges
Dirk Erpenbeck et al.
MOLECULAR PHYLOGENETICS AND EVOLUTION (2012)
Neurotoxicity of Brominated Flame Retardants: (In)direct Effects of Parent and Hydroxylated Polybrominated Diphenyl Ethers on the (Developing) Nervous System
Milou M. L. Dingemans et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2011)
Genotoxicity of Several Polybrominated Diphenyl Ethers (PBDEs) and Hydroxylated PBDEs, and Their Mechanisms of Toxicity
Kyunghee Ji et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2011)
Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1
Joachim Manns et al.
FASEB JOURNAL (2011)
LigPlot+: Multiple Ligand-Protein Interaction Diagrams for Drug Discovery
Roman A. Laskowski et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)
Polybrominated diphenyl ethers and their hydroxylated/methoxylated analogs: Environmental sources, metabolic relationships, and relative toxicities
Steve B. Wiseman et al.
MARINE POLLUTION BULLETIN (2011)
Identification of the natural product 2,3,4,5-tetrabromo-1-methylpyrrole in Pacific biota, passive samplers and seagrass from Queensland, Australia
Simon Gaul et al.
MARINE POLLUTION BULLETIN (2011)
Bromination Pattern of Hydroxylated Metabolites of BDE-47 Affects Their Potency to Release Calcium from Intracellular Stores in PC12 Cells
Milou M. L. Dingemans et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2010)
Brominated phenols, anisoles, and dioxins present in blue mussels from the Swedish coastline
Karin Lofstrand et al.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2010)
Spatial and temporal variability of the bacterial community in different chemotypes of the New Zealand marine sponge Mycale hentscheli
Sally A. Anderson et al.
FEMS MICROBIOLOGY ECOLOGY (2010)
Normal Development of Brain Circuits
Gregory Z. Tau et al.
NEUROPSYCHOPHARMACOLOGY (2010)
Calcium-Related Processes Involved in the Inhibition of Depolarization-Evoked Calcium Increase by Hydroxylated PBDEs in PC12 Cells
Milou M. L. Dingemans et al.
TOXICOLOGICAL SCIENCES (2010)
Structure-based investigation on the binding interaction of hydroxylated polybrominated diphenyl ethers with thyroxine transport proteins
Jie Cao et al.
TOXICOLOGY (2010)
Metabolism of Polybrominated Diphenyl Ethers (PBDEs) by Human Hepatocytes in Vitro
Heather M. Stapleton et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2009)
Origin of Hydroxylated Brominated Diphenyl Ethers: Natural Compounds or Man-Made Flame Retardants?
Yi Wan et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2009)
NMR Strategy for Unraveling Structures of Bioactive Sponge-Derived Oxy-polyhalogenated Diphenyl Ethers
Laurent Calcul et al.
JOURNAL OF NATURAL PRODUCTS (2009)
Effects of Decabrominated Diphenyl Ether (PBDE 209) Exposure at Different Developmental Periods on Synaptic Plasticity in the Dentate Gyrus of Adult Rats In Vivo
Tairan Xing et al.
TOXICOLOGICAL SCIENCES (2009)
Antifouling activity of sponge-derived polybrominated diphenyl ethers and synthetic analogues
Sofia Ortlepp et al.
BIOFOULING (2008)
Hydroxylated and methoxylated polybrominated diphenyl ethers and polybrominated dibenzo-p-dioxins in red alga and cyanobacteria living in the Baltic Sea
Anna Malmvarn et al.
CHEMOSPHERE (2008)
Levels and trends of HBCD and BDEs in the European and Asian environments, with some information for other BFRs
Robin J. Law et al.
CHEMOSPHERE (2008)
Bioactive Polybrominated diphenyl ethers from the marine sponge Dysidea sp.
Hui Zhang et al.
JOURNAL OF NATURAL PRODUCTS (2008)
Biotransformation of brominated flame retardants into potentially endocrine-disrupting metabolites, with special attention to 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47)
Timo Hamers et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2008)
PBDE-47-induced oxidative stress, DNA damage and apoptosis in primary cultured rat hippocampal neurons
Ping He et al.
NEUROTOXICOLOGY (2008)
DE-71-induced apoptosis involving intracellular calcium and the Bax-mitochondria-caspase protease pathway in human neuroblastoma cells In vitro
Ke Yu et al.
TOXICOLOGICAL SCIENCES (2008)
Biosensor discovery of thyroxine transport disrupting chemicals
Gerardo R. Marchesini et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2008)
Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels
Gennaro Giordano et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2008)
Polybrominated diphenyl ethers (PBDEs) and bioaccumulative hydroxylated PBDE metabolites in young humans from Managua, Nicaragua
Maria Athanasiadou et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2008)
In vitro effects of environmentally relevant polybrominated diphenyl ether (PBDE) congeners on calcium buffering mechanisms in rat brain
Cary G. Coburn et al.
NEUROCHEMICAL RESEARCH (2008)
Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants
Lucio G. Costa et al.
NEUROTOXICOLOGY (2007)
Distribution of polybrominated diphenyl ethers in human umbilical. cord serum, paternal serum, maternal serum, placentas, and breast milk from Madrid population, Spain
B. Gomara et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2007)
Neonatal exposure to brominated flame retardant BDE-47 reduces long-term potentiation and postsynaptic protein levels in mouse hippocampus
Milou M. L. Dingemans et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2007)
Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea
Novriyandi Hanif et al.
JOURNAL OF NATURAL PRODUCTS (2007)
Prenatal exposure to polybrominated diphenylether 99 enhances the function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and in cultured neurons
Marta Llansola et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2007)
Apoptosis: A review of programmed cell death
Susan Elmore
TOXICOLOGIC PATHOLOGY (2007)
Neurotoxicity of the pentabrominated diphenyl ether mixture, DE-71, and hexabromocyclododecane (HBCD) in rat cerebellar granule cells in vitro
Trine Reistad et al.
ARCHIVES OF TOXICOLOGY (2006)
Extra precision glide: Docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes
Richard A. Friesner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
In vitro profiling of the endocrine-disrupting potency of brominated flame retardants
Timo Hamers et al.
TOXICOLOGICAL SCIENCES (2006)
Identification of hydroxylated metabolites in 2,2′,4,4′-tetrabromodiphenyl ether exposed rats
G Marsh et al.
CHEMOSPHERE (2006)
Drug discovery from natural sources
Young-Won Chin et al.
AAPS JOURNAL (2006)
Effects of polybrominated diphenol ethers from a marine sponge Phyllospongia dendyi on IL-8 production in a PMA-stimulated promyelocytic leukemia cell line
Taiko Oda et al.
MARINE DRUGS (2005)
Identification, quantification, and synthesis of a novel dimethoxylated polybrominated biphenyl in marine mammals caught off the coast of Japan
G Marsh et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2005)
Corallinafuran and corallinaether, novel toxic compounds from crustose coralline red algae
M Kitamura et al.
CHEMISTRY LETTERS (2005)
Identification of hydroxylated polybrominated diphenyl ether metabolites in blood plasma from polybrominated diphenyl ether exposed rats
T Malmberg et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2005)
Identification of the cellular site of polychlorinated peptide biosynthesis in the marine sponge Dysidea (Lamellodysidea) herbacea and symbiotic cyanobacterium Oscillatoria spongeliae by CARD-FISH analysis
P Flatt et al.
MARINE BIOLOGY (2005)
Antifungal effect and possible mode of activity of a compound from the marine sponge Dysidea herbacea
E Sionov et al.
JOURNAL OF INFECTION (2005)
Marine sponge Dysidea herbacea revisited:: Another brominated diphenyl ether
Madhavi S. Agrawal et al.
MARINE DRUGS (2005)
Two abundant bioaccumulated halogenated compounds are natural products
EL Teuten et al.
SCIENCE (2005)
Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase
YM Xu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Isolation and characterization of polybrominated diphenyl ethers as inhibitors of microtubule assembly from the marine sponge Phyllospongia dendyi collected at Palau
HW Liu et al.
JOURNAL OF NATURAL PRODUCTS (2004)
Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase
EN Segraves et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Ortho-substituted PCBs kill cells by altering membrane structure
YS Tan et al.
TOXICOLOGICAL SCIENCES (2004)
Differential in vitro neurotoxicity of the flame retardant PBDE-99 and of the PCB Aroclor 1254 in human astrocytoma cells
F Madia et al.
TOXICOLOGY LETTERS (2004)
Synthesis, activity, and molecular modeling studies of novel human aldose reductase inhibitors based on a marine natural product
JA de la Fuente et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold
L Kissau et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Polybrominated diphenyl ethers in maternal and fetal blood samples
A Mazdai et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2003)
Ortho-substituted PCBs kill thymocytes
YS Tan et al.
TOXICOLOGICAL SCIENCES (2003)
Tissue disposition, excretion and metabolism of 2,2′,4,4′,5-pentabromodiphenyl ether (BDE-99) in the male Sprague-Dawley rat
H Hakk et al.
XENOBIOTICA (2002)
Brominated flame retardants in archived serum samples from Norway: A study on temporal trends and the role of age
C Thomsen et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2002)
Spongiadioxins A and B, two new polybrominated dibenzo-p-dioxins from an Australian marine sponge Dysidea dendyi
NK Utkina et al.
JOURNAL OF NATURAL PRODUCTS (2001)
Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro
IATM Meerts et al.
TOXICOLOGICAL SCIENCES (2000)
Critical periods of vulnerability for the developing nervous system: Evidence from humans and animal models
D Rice et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2000)
Cleavage of poly(ADP-ribose) polymerase measured in situ in individual cells:: Relationship to DNA fragmentation and cell cycle position during apoptosis
X Li et al.
EXPERIMENTAL CELL RESEARCH (2000)