Journal
MOLECULAR PSYCHIATRY
Volume 26, Issue 9, Pages 5161-5170Publisher
SPRINGERNATURE
DOI: 10.1038/s41380-021-01020-5
Keywords
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Funding
- National Institute on Aging [U01AG029824]
- National Health and Medical Research Council of Australia [1081901, 334047, 1127060]
- NHMRC Senior Principal Research Fellowship [1059660, 1156072]
- National Cancer Institute at the National Institutes of Health
- National Health and Medical Research Council of Australia [1081901] Funding Source: NHMRC
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The study found that aspirin did not have any long-term benefits on late-life depression in a sample of older adults over a 5-year period. On the contrary, it showed a negative impact on the course of depression in those with pre-existing depressive symptoms.
Late-life depression is common and often inadequately managed using existing therapies. Depression is also associated with increased markers of inflammation, suggesting a potential role for anti-inflammatory agents. ASPREE-D is a sub-study of ASPREE, a large multi-centre, population-based, double-blind, placebo-controlled trial of aspirin vs placebo in older Australian and American adults (median follow-up: 4.7 years) of whom 1879 were depressed at baseline. Participants were given 100 mg daily dose of aspirin or placebo. Depressive symptoms were assessed annually using the validated, self-rated short version of the Center for Epidemiological Studies Depression scale. There was a significant increase in depressive scores (0.6; 95% CI 0.2 to 0.9; chi(2) (1) = 10.37; p = 0.001) and a decreased score in the mental health component of a quality of life scale (-0.7; 95% CI -1.4 to -0.1; chi(2) (1) = 4.74; p = 0.029) in the aspirin group compared to the placebo group. These effects were greater in the first year of follow-up and persisted throughout the study, albeit with small to very small effect sizes. This study failed to demonstrate any benefit of aspirin in the long-term course of depression in this community-dwelling sample of older adults over a 5-year period, and identified an adverse effect of aspirin in the course of depression in those with pre-existing depressive symptoms.
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