Journal
MOLECULAR IMMUNOLOGY
Volume 130, Issue -, Pages 14-19Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2020.12.006
Keywords
T cells; Lipids; CD1 antigen presenting molecules; Skin
Categories
Funding
- National Institute of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases [NIAMS R01 AR074037, K01 AR068475]
- UK Medical Research Council
- NIHR Clinical Research Network
- British Association of Dermatologists
- British Skin Foundation
- Wellcome Trust
- NIHR Oxford Biomedical Research Centre (BRC)
- Misses Barrie Charitable Trust
- MRC [MC_UU_00008/5, MC_EX_MR/R022550/1, G116/150, MC_U137881017, MC_UU_12010/5] Funding Source: UKRI
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The high expression of CD1a on Langerhans cells in normal human skin indicates its crucial role in skin homeostasis and immunity. While the lipid antigen presenting function of CD1a has been known for years, the physiological and pathological functions of the CD1a system in human skin are still not fully understood. Recent research provides insights into the functions of CD1a, CD1a-restricted T cells, and lipid antigens in inflammatory and allergic skin diseases.
The high expression of CD1a on Langerhans cells in normal human skin suggests a central role for this lipid antigen presenting molecule in skin homeostasis and immunity. Although the lipid antigen presenting function of CD1a has been known for years, the physiological and pathological functions of the CD1a system in human skin remain incompletely understood. This review provides an overview of this active area of investigation, and discusses recent insights into the functions of CD1a, CD1a-restricted T cells, and lipid antigens in inflammatory and allergic skin disease. We include recent publications and work presented at the biennial CD1-MR1 EMBO workshop held in 2019 in Oxford, regarding lipids that increase and those that decrease T cell responses to CD1a.
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