Journal
MOLECULAR CELL
Volume 81, Issue 7, Pages 1372-1383Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2021.02.022
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Funding
- National Institutes of Health (NIH) [R37GM059425, 5T32GM007445-39]
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Eukaryotic cells integrate multiple quality control responses during protein synthesis, signaled by slow or stalled elongating ribosomes. Depending on the nature of the delay, the signal may lead to translational repression, messenger RNA decay, ribosome rescue, and/or nascent protein degradation. The structure and composition of an elongating ribosome in a troubled state determine the downstream quality control pathways involved, highlighting the intersecting pathways between RNA decay and ribosome rescue.
Eukaryotic cells integrate multiple quality control (QC) responses during protein synthesis in the cytoplasm. These QC responses are signaled by slow or stalled elongating ribosomes. Depending on the nature of the delay, the signal may lead to translational repression, messenger RNA decay, ribosome rescue, and/or nascent protein degradation. Here, we discuss how the structure and composition of an elongating ribosome in a troubled state determine the downstream quality control pathway(s) that ensue. We highlight the intersecting pathways involved in RNA decay and the crosstalk that occurs between RNA decay and ribosome rescue.
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