Related references
Note: Only part of the references are listed.Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition
Ashwini Hinge et al.
CELL STEM CELL (2020)
Understanding intrinsic hematopoietic stem cell aging
Eva Mejia-Ramirez et al.
HAEMATOLOGICA (2020)
Microenvironmental contributions to hematopoietic stem cell aging
Ya-Hsuan Ho et al.
HAEMATOLOGICA (2020)
Interplay between Clonal Hemtopoiesis of Indeterminate Potential and Metabolism
Man K. S. Lee et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2020)
Activation of AMPK under Hypoxia: Many Roads Leading to Rome
Franziska Dengler
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Mechanisms and rejuvenation strategies for aged hematopoietic stem cells
Xia Li et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)
Regulation of the Bone Marrow Niche by Inflammation
Ioannis Mitroulis et al.
FRONTIERS IN IMMUNOLOGY (2020)
Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity
Lydia Kalafati et al.
CELL (2020)
Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities
Marie-Dominique Filippi et al.
BLOOD (2019)
Haematopoietic stem cell activity and interactions with the niche
Sandra Pinho et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
The Unique Metabolic Characteristics of Bone Marrow Adipose Tissue
Yujue Li et al.
FRONTIERS IN ENDOCRINOLOGY (2019)
Therapeutic targeting of trained immunity
Willem J. M. Mulder et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation
Evgenia V. Verovskaya et al.
TRENDS IN MOLECULAR MEDICINE (2019)
The Roles of Cholesterol and Its Metabolites in Normal and Malignant Hematopoiesis
Hideyuki Oguro
FRONTIERS IN ENDOCRINOLOGY (2019)
Allicin alleviates lead-induced hematopoietic stem cell aging by up-regulating PKM2
Shi-zhong Cai et al.
BIOSCIENCE REPORTS (2019)
Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation
Triantafyllos Chavakis et al.
NATURE IMMUNOLOGY (2019)
ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection
Jayna J. Mistry et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Clonal hematopoiesis in human aging and disease
Siddhartha Jaiswal et al.
SCIENCE (2019)
Immunometabolic Crosstalk: An Ancestral Principle of Trained Immunity?
Sider Penkov et al.
TRENDS IN IMMUNOLOGY (2019)
Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic lschemic Heart Failure
Lena Dorsheimer et al.
JAMA CARDIOLOGY (2019)
Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming
Anette Christ et al.
CELL (2018)
Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity
Ioannis Mitroulis et al.
CELL (2018)
Hematopoietic stem cell fate through metabolic control
Kyoko Ito et al.
EXPERIMENTAL HEMATOLOGY (2018)
Ca2+- mitochondria axis drives cell division in hematopoietic stem cells
Terumasa Umemoto et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2018)
Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation
Qicong Shen et al.
NATURE (2018)
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host
Marlies Meisel et al.
NATURE (2018)
Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage
Paula Gutierrez-Martinez et al.
NATURE CELL BIOLOGY (2018)
Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis
Bin Guo et al.
NATURE MEDICINE (2018)
Myelodysplastic syndromes current treatment algorithm 2018
David P. Steensma
BLOOD CANCER JOURNAL (2018)
SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function
Jie Sun et al.
CELL STEM CELL (2018)
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer
Di Wu et al.
NATURE (2018)
Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis
Zhigang Cai et al.
CELL STEM CELL (2018)
Clinical consequences of clonal hematopoiesis of indeterminate potential
David P. Steensma
BLOOD ADVANCES (2018)
From haematopoietic stem cells to complex differentiation landscapes
Elisa Laurenti et al.
NATURE (2018)
FOXO3 Transcription Factor Is Essential for Protecting Hematopoietic Stem and Progenitor Cells from Oxidative DNA Damage
Carolina L. Bigarella et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway
Yang Zhao et al.
MOLECULAR CANCER (2017)
Autophagy maintains the metabolism and function of young and old stem cells
Theodore T. Ho et al.
NATURE (2017)
Ascorbate regulates haematopoietic stem cell function and leukaemogenesis
Michalis Agathocleous et al.
NATURE (2017)
Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation
Xin Liu et al.
NATURE CELL BIOLOGY (2017)
The mitochondrial respiratory chain is essential for haematopoietic stem cell function
Elena Anso et al.
NATURE CELL BIOLOGY (2017)
DNA damage tolerance in hematopoietic stem and progenitor cells in mice
Bas Pilzecker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
Jose J. Fuster et al.
SCIENCE (2017)
Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment
Kristina Kirschner et al.
CELL REPORTS (2017)
NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts
Christopher R. Marlein et al.
BLOOD (2017)
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression
Luisa Cimmino et al.
CELL (2017)
Adult haematopoietic stem cell niches
Genevieve M. Crane et al.
NATURE REVIEWS IMMUNOLOGY (2017)
DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions
Manuel Buscarlet et al.
BLOOD (2017)
The PI3K Pathway in Human Disease
David A. Fruman et al.
CELL (2017)
CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression
David H. Spencer et al.
CELL (2017)
The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism
Pengxu Qian et al.
CELL STEM CELL (2016)
Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential
Larry L. Luchsinger et al.
NATURE (2016)
Specification of haematopoietic stem cell fate via modulation of mitochondrial activity
Nicola Vannini et al.
NATURE COMMUNICATIONS (2016)
Resveratrol Supplementation in Schizophrenia Patients: A Randomized Clinical Trial Evaluating Serum Glucose and Cardiovascular Risk Factors
Karine Zortea et al.
NUTRIENTS (2016)
Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment
Larisa V. Kovtonyuk et al.
FRONTIERS IN IMMUNOLOGY (2016)
Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies
Melissa A. Moser et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)
TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia
Jumpei Yamazaki et al.
CANCER RESEARCH (2015)
Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock
Charlie R. Mantel et al.
CELL (2015)
Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3
Pauline Rimmele et al.
EMBO REPORTS (2015)
Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis
Kasper D. Rasmussen et al.
GENES & DEVELOPMENT (2015)
Neutrophil ageing is regulated by the microbiome
Dachuan Zhang et al.
NATURE (2015)
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
Dagmar Walter et al.
NATURE (2015)
A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
Mary Mohrin et al.
SCIENCE (2015)
The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice
Qing-Shuo Zhang et al.
STEM CELL RESEARCH (2015)
An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate
Maria Maryanovich et al.
NATURE COMMUNICATIONS (2015)
Resveratrol increases the bone marrow hematopoietic stem and progenitor cell capacity
Pauline Rimmele et al.
AMERICAN JOURNAL OF HEMATOLOGY (2014)
Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis
Ying-Hua Wang et al.
CELL (2014)
Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection
Arya Khosravi et al.
CELL HOST & MICROBE (2014)
A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function
Dongryeol Ryu et al.
CELL METABOLISM (2014)
AMPK at the Nexus of Energetics and Aging
Kristopher Burkewitz et al.
CELL METABOLISM (2014)
Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression
Chia-Wei Cheng et al.
CELL STEM CELL (2014)
Glucose and Glutamine Metabolism Regulate Human Hematopoietic Stem Cell Lineage Specification
Leal Oburoglu et al.
CELL STEM CELL (2014)
DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies
A. P. Im et al.
LEUKEMIA (2014)
The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress
Peter van Galen et al.
NATURE (2014)
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
Johanna Flach et al.
NATURE (2014)
Metabolic requirements for the maintenance of self-renewing stem cells
Keisuke Ito et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
Giulio Genovese et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
Siddhartha Jaiswal et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Surviving change: the metabolic journey of hematopoietic stem cells
Latika Kohli et al.
TRENDS IN CELL BIOLOGY (2014)
Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance
Maria Casanova-Acebes et al.
CELL (2013)
Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis
Prabhakara R. Nagareddy et al.
CELL METABOLISM (2013)
Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells
Keiyo Takubo et al.
CELL STEM CELL (2013)
Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation
Wen-Mei Yu et al.
CELL STEM CELL (2013)
The migration of hematopoietic progenitors from the fetal liver to the fetal bone marrow: Lessons learned and possible clinical applications
Jesus Ciriza et al.
EXPERIMENTAL HEMATOLOGY (2013)
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
Omar Abdel-Wahab et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2013)
FOXO3A directs a protective autophagy program in haematopoietic stem cells
Matthew R. Warr et al.
NATURE (2013)
The ageing haematopoietic stem cell compartment
Hartmut Geiger et al.
NATURE REVIEWS IMMUNOLOGY (2013)
ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression
Omar Abdel-Wahab et al.
CANCER CELL (2012)
Metabolic Plasticity in Stem Cell Homeostasis and Differentiation
Clifford D. L. Folmes et al.
CELL STEM CELL (2012)
The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia
L. Willems et al.
LEUKEMIA (2012)
Dnmt3a is essential for hematopoietic stem cell differentiation
Grant A. Challen et al.
NATURE GENETICS (2012)
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
Lambert Busque et al.
NATURE GENETICS (2012)
A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
Keisuke Ito et al.
NATURE MEDICINE (2012)
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
Wei Xu et al.
CANCER CELL (2011)
Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation
Kelly Moran-Crusio et al.
CANCER CELL (2011)
Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging
Gudmundur L. Norddahl et al.
CELL STEM CELL (2011)
AMP-activated protein kinase-an energy sensor that regulates all aspects of cell function
D. Grahame Hardie
GENES & DEVELOPMENT (2011)
ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice
Andrew J. Murphy et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
Monika Mortensen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells
Brad Dykstra et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Epigenetics of haematopoietic cell development
Howard Cedar et al.
NATURE REVIEWS IMMUNOLOGY (2011)
Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice
Michael G. Kharas et al.
BLOOD (2010)
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species
Marisa M. Juntilla et al.
BLOOD (2010)
Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis
Mary Mohrin et al.
CELL STEM CELL (2010)
The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche
Tugba Simsek et al.
CELL STEM CELL (2010)
Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells
Keiyo Takubo et al.
CELL STEM CELL (2010)
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
Amar J. Majmundar et al.
MOLECULAR CELL (2010)
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
Daisuke Nakada et al.
NATURE (2010)
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
Boyi Gan et al.
NATURE (2010)
The emerging mechanisms of isoform-specific PI3K signalling
Bart Vanhaesebroeck et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation
Laurent Yvan-Charvet et al.
SCIENCE (2010)
Oxygen homeostasis
Gregg L. Semenza
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2010)
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
Omar Abdel-Wahab et al.
BLOOD (2009)
Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms
Anna M. Jankowska et al.
BLOOD (2009)
Systems biology of stem cell fate and cellular reprogramming
Ben D. MacArthur et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani et al.
SCIENCE (2009)
mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells
Chong Chen et al.
SCIENCE SIGNALING (2009)
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
David B. Shackelford et al.
NATURE REVIEWS CANCER (2009)
Mechanisms of asymmetric stem cell division
Juergen A. Knoblich
CELL (2008)
DNA-damage repair; the good, the bad, and the ugly
Razqallah Hakem
EMBO JOURNAL (2008)
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
Chong Chen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
Yoon-Young Jang et al.
BLOOD (2007)
Foxo3a is essential for maintenance of the hematopoietic stem cell pool
Kana Miyamoto et al.
CELL STEM CELL (2007)
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
Derrick J. Rossi et al.
NATURE (2007)
Myeloid lineage commitment from the hematopoietic stem cell
Hirorni Iwasaki et al.
IMMUNITY (2007)
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
Zuzana Tothova et al.
CELL (2007)
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
K Ito et al.
NATURE (2004)
C-elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
ACR Epstein et al.
CELL (2001)
Share Paper
