Journal
MOLECULAR AND CELLULAR BIOCHEMISTRY
Volume 476, Issue 5, Pages 2085-2097Publisher
SPRINGER
DOI: 10.1007/s11010-021-04064-x
Keywords
BMP10; Lipid metabolism; Myogenesis
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Funding
- National Research Foundation of Korea - Korean government (MSIT) [2019R1A2C2002163]
- National Research Foundation of Korea [2019R1A2C2002163] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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BMP10 plays crucial roles in muscle physiology by promoting myogenic differentiation, glucose uptake, and lipid catabolism, mainly via the Smad 1/5/8 signaling pathway.
BMP10 plays an essential role in regulating cardiac growth, chamber maturation, and maintaining normal expressions of several key cardiogenic factors; however, other functional roles of BMP10 in muscle remain unexplored. This study therefore undertook to investigate the roles of BMP10 in muscle physiology, using mouse-derived C2C12 myoblasts. Bmp10 silencing prevented a number of biological processes such as myogenic differentiation, glucose uptake, and lipid catabolism, whereas exogenous induction of BMP10 in C2C12 cells significantly stimulated the expression of proteins and genes involved in these processes, as well as mitochondrial biogenesis and thermogenesis, resulting in reduced lipid accumulation. A mechanistic study revealed that BMP10 stimulates myogenesis mainly via the Smad 1/5/8 signaling pathway. In conclusion, our data unveiled a previously unknown mechanism in the regulation of lipid metabolisms by BMP10 in muscle cells and identified its significant roles in systemic metabolic homeostasis, shedding light on BMP10 as a pharmacotherapeutic target to treat metabolic disorders.
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