Journal
MINI-REVIEWS IN ORGANIC CHEMISTRY
Volume 19, Issue 1, Pages 74-91Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570193X18666210218212719
Keywords
Pyridine-3-carbonitrile; pyrimidine-5-carbonitrile; 3-aminothiophene-2-carbonitrile; iodoisoquinolines; mercapto-benzoquinolinones; synthesis; reactivity
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This review describes the synthesis and chemical reactivity of tetrahydrothieno[3,2-b] quinoline derivatives using various reagents, and the reactions involved in their synthesis.
This review describes the synthesis and chemical reactivity of tetrahydrothieno[3,2-b] quinoline derivatives through many reagents such as; 1, 2-dihydropyridine-3-carbonitrile; 1,6-dihydropyrimidine-5-carbonitrile; 2,3-dihydropyridazine-4-carbonitrile; 3-amino-thiophene-2-carboxylate; 3amino-thiophene-2-carbonitrile; 3,4-diaminothieno[2,3-b] thiophene-2,5-dicarbo-nitrile; 2-(3-bromo-1iodoisoquinolin-8-yl) benzonitrile and 3-mercapto-benzo[g]quinolin-4(1H)-one derivatives. The synthesis of tetrahydrothieno [3, 2-b] quinoline derivatives was explained through the following chemical reactions: Aldol condensation, alkylation, cyclocondensation, dehydration, chlorination, Wolff-Kishner reduction, acylation, Friedlander reaction and intramolecular cyclization.
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