Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 21, Issue 20, Pages 3219-3248Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557521666210304111754
Keywords
Multi-target-directed-ligands; alzheimer's disease; quinoline; chromene; carbazole
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Funding
- CSIR-JRF
- UGC-MANF [201819-MANF-2018-19-RAJ-91971]
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Dementia is a chronic neurodegenerative disease, with Alzheimer's disease being the main cause, posing a national crisis in India with over 4 million cases. Traditional drugs target only one factor, leading scientists to focus on developing multi-target-directed agents incorporating multiple active scaffolds.
Dementia is a chronic neurodegenerative disease, and a maximum number of the cases are directly related to Alzheimer's disease. More than 4 million people are living with Alzheimer's disease-related dementia in India, making it a national crisis. Alzheimer's disease deteriorates cognitive functions with the passage of time and consists of multi-faceted factors, such as the decline of acetylcholine level, amyloid beta-aggregation, tau hyperphosphorylation, oxidative stress, etc. The classical drugs used to date, are focused on only one target and are not serving the cause properly. Hence, the community of scientists is rigorously working on multi-target-directed agents that incorporate two or more active scaffolds in one compound or hybrid of active moieties. This article aims to evaluate novel potential compounds and moieties, such as quinolines, chalcones, coumarins, chromenes, piperazine, carbazoles, cinnamic acids, tacrine hybrids, donepezil hybrids, etc., that have been introduced as multi-target-directed agents in the recent five years.
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