Fabrication of handmade paper sensor based on silver-cobalt doped copolymer-ionic liquid composite for monitoring of vitamin D3 level in real samples

This paper describes the synthesis of novel material and its application to fabricate a sensing tool for the diagnosis of vitamin D deficiency. A simple and economical route for the synthesis of novel composite material based on silver-cobalt (Co-Ag) doped polyaniline-polypyrrole (PANI-PPY) copolymer and ionic liquid (IL) has been described and used as sensing material for vitamin D-3 detection. The synthesized composite was characterized using structural, morphological and electrochemical techniques. Co-Ag/PANI-PPY/IL was first used to modify the glassy carbon electrode (GCE) and applied for vitamin D(3 )detection. Later a conductive ink of the proposed material was prepared and a handmade paper sensor was fabricated. Co-Ag/PANI-PPY/IL@GCE and paper electrode showed excellent electrochemical behavior towards vitamin D-3 oxidation within the concentration range of 0.0125-22.5 mu M and 0.025-0.125 mu M with the acceptable detection limit of 0.0073 mu M and 0.015 mu M respectively. Co-Ag/PANI-PPY/IL@GCE and paper electrode were successfully applied for the detection of vitamin D-3 in serum and urine samples.

Automated summary

This paper discusses the synthesis and application of a novel composite material for the fabrication of a sensor for detecting vitamin D deficiency. The material shows excellent electrochemical behavior towards vitamin D-3 oxidation and has been successfully applied for the detection of vitamin D-3 in serum and urine samples.