4.2 Article

The changes of respiratory microbiome between mild and severe asthma patients

Journal

MICROBIOLOGY AND IMMUNOLOGY
Volume 65, Issue 5, Pages 204-213

Publisher

WILEY
DOI: 10.1111/1348-0421.12881

Keywords

asthma; bioinformatics; microbiome; microbiome function; respiratory

Funding

  1. Public Welfare Technology Applied Research Projects in Zhejiang province [LGF19H010004, 2017C33195]
  2. Science and Technology Research Plan of Jinhua City, China [2018-3-022, 2019-3019]
  3. Zhejiang Medical and Health Science and Technology Plan Project [2019KY746]

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This study found that there were significant changes in the components and the function of the microbiome when asthma changed from mild to severe, which can help us better understand the relationship between asthma and the respiratory microbiome.
Due to the increased number of patients suffering from asthma, the mechanism of this disease has been subject to much attention from the public and finding a cure for this disease is urgent. A changed abundance of the microbiome has been proven to play an important role in the genesis and development of asthma. In this study, the abundance and the function of the microbiome were studied. It was found that there were significant changes in the components and the function of the microbiome when asthma changed from mild to severe. This study could help us to better understand the relationship between asthma and the respiratory microbiome.

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