Roles for fibroblast growth factor-23 and alpha-Klotho in acute kidney injury

Acute kidney injury is a global disease with high morbidity and mortality. Recent studies have revealed that the fibroblast growth factor-23-alpha-Klotho axis is closely related to chronic kidney disease, and has multiple biological functions beyond bone-mineral metabolism. However, although dysregulation of fibroblast growth factor-23 -alpha-Klotho has been observed in acute kidney injury, the role of fibroblast growth factor-23-alpha-Klotho in the pathophysiology of acute kidney injury remains largely unknown. In this review, we describe recent findings regarding fibroblast growth factor-23-alpha-Klotho, which is mainly involved in inflammation, oxidative stress, and hemodynamic disorders. Further, based on these recent results, we put forth novel insights regarding the relationship between the fibroblast growth factor-23-alpha-Klotho axis and acute kidney injury, which may provide new therapeutic targets for treating acute kidney injury. (c) 2020 Elsevier Inc. All rights reserved.

Automated summary

The fibroblast growth factor-23-alpha-Klotho axis is closely related to chronic kidney disease and has multiple biological functions beyond bone-mineral metabolism. Dysregulation of this axis has been observed in acute kidney injury, but its exact role in the pathophysiology of acute kidney injury remains largely unknown. It may provide new therapeutic targets for treating acute kidney injury.