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A proteolytic cascade of kallikreins in the stratum corneum
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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2005)
Calcitonin gene-related peptide receptor antagonist BIBN4096BS for the acute treatment of migraine
J Olesen et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Discovery and SAR development of 2-(phenylamino) imidazolines as postacyclin receptor antagonists
RD Clark et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity
PL Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
In vitro activity of AVE1330A, an innovative broad-spectrum non-β-lactam β-lactamase inhibitor
A Bonnefoy et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2004)
Diazepinomicin, a new antimicrobial alkaloid from a marine Micromonospora sp.
RD Charan et al.
JOURNAL OF NATURAL PRODUCTS (2004)
Monanchorin, a bicyclic alkaloid from the sponge Monanchora ungiculata
KM Meragelman et al.
JOURNAL OF NATURAL PRODUCTS (2004)
Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infection
KV Kibler et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function
VSRK Yedavalli et al.
CELL (2004)
Discovery of a potent and selective αvβ3 integrin antagonist with strong inhibitory activity against neointima formation in rat balloon injury model
S Iwama et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Potent inhibition of NTPase/helicase of the West Nile virus by ring-expanded (Fat) nucleoside analogues
N Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Ring-expanded (fat) nucleoside and nucleotide analogues exhibit potent in vitro activity against Flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus
N Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones:: Orally active inhibitors of lck kinase
DR Goldberg et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses
P Borowski et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2003)
Cyclic amidines as benzamide bioisosteres:: EPC synthesis and SAR studies leading to the selective dopamine D4 receptor agonist FAUC 312
J Einsiedel et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
In vitro inhibition of the measles virus by novel ring-expanded ('fat') nucleoside analogues containing the imidazo[4,5-e][1,3]diazepine ring system
N Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002)
Novel benzthiodiazepinones as antiherpetic agents: SAR improvement of therapeutic index by alterations of the seven-membered ring
HW Hamilton et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002)
Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives:: Potent A2A- and A3-adenosine receptor antagonists
CE Müller et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Characterization of imidazo[4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase:: Evidence for activity on the level of substrate and/or enzyme
P Borowski et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2002)
Synthesis and in vitro muscarinic activities of a series of 1,3-diazacycloalkyl carboxaldehyde oxime derivatives
R Plate et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2002)
New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease
G Kleymann et al.
NATURE MEDICINE (2002)
New insights into the molecular actions of serotonergic antimigraine drugs
PL Durham et al.
PHARMACOLOGY & THERAPEUTICS (2002)
Novel ring-expanded nucleoside analogs exhibit potent and selective inhibition of hepatitis B virus replication in cultured human hepatoblastoma cells
RK Sood et al.
ANTIVIRAL RESEARCH (2002)
Drug therapy: Migraine - Current understanding and treatment.
PJ Goadsby et al.
NEW ENGLAND JOURNAL OF MEDICINE (2002)
A unique ring-expanded acyclic nucleoside analogue that inhibits both adenosine deaminase (ADA) and guanine deaminase (GDA; guanase):: Synthesis and enzyme inhibition studies of 4,6-diamino-8H-1-hydroxyethoxymethyl-8-iminoimidazo[4,5-e][1,3]diazepine
LJ Wang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001)
Migraine diagnosis and treatment: Results from the American Migraine Study II
RB Lipton et al.
HEADACHE (2001)
AMP deaminase inhibitors. 5. Design, synthesis, and SAR of a highly potent inhibitor series
SR Kasibhatla et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
Cyclopropyl building blocks for organic synthesis part 64 -: Facile preparation of hexahydropyrrolo[3,2-e][1,4]diazepine-2,5-diones and tetrahydrofuro[1H][3,2-e][1,4]diazepine-2,5-diones by rearrangements of cyclopropylketimines and cyclopropylketones
C Funke et al.
ORGANIC LETTERS (2000)
Plants used against cancer - an extension of the work of Jonathan Hartwell
JG Graham et al.
JOURNAL OF ETHNOPHARMACOLOGY (2000)
The role of quorum sensing in the in vivo virulence of Pseudomonas aeruginosa
KP Rumbaugh et al.
MICROBES AND INFECTION (2000)
Discovery of (R)-7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity
JT Hunt et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
New substituted 1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-yl derivatives with α2-adrenoceptor antagonist activity
P Mayer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Molecular mechanisms that confer antibacterial drug resistance
C Walsh
NATURE (2000)
A novel class of zinc-binding inhibitors for the phosphatidylcholine-preferring phospholipase C from Bacillus cereus
SF Martin et al.
JOURNAL OF ORGANIC CHEMISTRY (2000)
AMP deaminase inhibitors. 3. SAR of 3-(carboxyarylalkyl)coformycin aglycon analogues
SR Kasibhatla et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
AMP deaminase inhibitors. 2. Initial discovery of a non-nucleotide transition-state inhibitor series
BC Bookser et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
AMP deaminase inhibitors.: 4.: Further N3-substituted coformycin aglycon analogues:: N3-alkylmalonates as ribose 5′-monophosphate mimetics
BC Bookser et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Synthesis of C2-symmetric guanidino-sugars as potent inhibitors of glycosidases
Y Le Merrer et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2000)
The RNA helicase and nucleotide triphosphatase activities of the bovine viral diarrhea virus NS3 protein are essential for viral replication
BH Gu et al.
JOURNAL OF VIROLOGY (2000)
Can HCV affect the efficacy of anti-HIV treatment?
P Filippini et al.
ARCHIVES OF VIROLOGY (2000)