Journal
MATURITAS
Volume 148, Issue -, Pages 46-53Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.maturitas.2021.03.005
Keywords
Serum uric acid; Hip fracture; Vorarlberg Health Monitoring and Promotion; Program; Osteoporosis
Categories
Funding
- state of Vorarlberg
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This study revealed a close association between serum uric acid and the risk of hip fractures in both women and men, with a more pronounced increase in risk in men.
Objectives: Serum markers that can be used to estimate the risk of bone fractures are rare, and findings for one candidate marker, uric acid, are heterogeneous. Our aim was to investigate the potential of serum uric acid (SUA) to predict hip fractures occurring in people aged 50 years and over. Study design: During a medical prevention program over the period 1985-2005 in Vorarlberg, baseline data were collected on SUA levels and covariates (age, BMI, blood pressure, smoking status, diabetes, triglycerides and cholesterol) from 185,397 individuals, of whom 42,488 women and 35,908 men met the inclusion criteria of this population-based cohort study. Information on incident cancer and end-stage kidney disease was acquired from registries. Main outcome measure: Incident hip fracture occurring in participants aged 50 years and over during the observation period 2003-2013. Results: SUA was associated with a rise in female hip fracture risk by 6% per unit increase (HR 1.06, 95 %-CI 1.01-1.10), and risk in the highest vs. lowest SUA quartile was significantly increased (HR 1.17, 95 %-CI 1.01-1.35), but not at hyperuricemic (>5.7 mg/dl) vs. normouricemic (<5.7 mg/dl) levels. In men, hip fracture risk rose by 15 % per unit increase (HR 1.15, 95 %-CI 1.08-1.22), and risk was significantly higher in the highest vs. lowest SUA quartile (HR 1.50, 95 %-CI 1.17-1.91) as well as at hyperuricemic (>7.0 mg/dl) vs. normouricemic (<7.0 mg/dl) levels (HR 1.48, 95 %-CI 1.19-1.84). Conclusions: Our results link SUA with increased risk of hip fractures, particularly in men.
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