Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 119, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2020.111555
Keywords
Recombinant human collagen-peptide; Chitosan; EDC; Thermosensitive hydrogels; Wound healing
Categories
Funding
- National High-tech Research and Development Program of China [2014AA022107]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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Thermoresponsive hydrogels formed by conjugating recombinant human collagen-peptide (RHC) with chitosan exhibit lower gelation temperature and superior mechanical strength, showing good biocompatibility with cells and promoting cell infiltration, vessel formation, and wound healing. Overall, the use of RHC-chitosan hydrogels is a promising and effective therapeutic approach for burn wound treatment.
Thermosensitive chitosan hydrogels have been widely used in drug delivery and tissue repair, but further applications of these hydrogels have been limited by their weak mechanical strength and poor bioactivity. A thermoresponsive hydrogel formed by conjugating recombinant human collagen-peptide (RHC) with chitosan might be better suited for cell encapsulation and wound repair. RHC-chitosan hydrogels were prepared and tested, and the results showed that moderate RHC conjugation led to hydrogels with lower gelation temperature. The prepared RHC-containing hydrogels showed superior mechanical strength to chitosan-only hydrogels. Additionally, cells exhibited superior viability when cultured with RHC-modified hydrogels compared with hydrogels that had not been conjugated with RHC. Finally, RHC-chitosan hydrogels were injected onto the backs of rats with second-degree burns and promoted cell infiltration, vessel formation, and wound healing. Overall, the use of RHC-chitosan hydrogels is a promising and effective therapeutic approach for burn wound treatment.
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