Journal
MATERIALS LETTERS
Volume 285, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.matlet.2020.129100
Keywords
Polyhydroxyalkanoates; mcl-PHA; Titanium dioxide; Composites; Biocompatibility
Funding
- Ministry of Education, Science and Technological Development of the Republic of Serbia [173048]
- Swiss National Science Foundation (SNSF) [IZSEZ0_186495, 205321_173012]
- COST Action [CA-16217 ENIUS]
- Science Foundation Ireland (SFI) under AMBER Grant [12/RC/2278_P2]
- National Centre for Research and Development, Poland [LIDER/27/0090/L-7/15/NCBR/2016]
- Swiss National Science Foundation (SNF) [IZSEZ0_186495, 205321_173012] Funding Source: Swiss National Science Foundation (SNF)
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New polyhydroxyoctanoate (PHO)/TiO2 composites were produced, showing tunable properties with preserved flexibility and increased stiffness compared to neat PHO. Biocompatibility and cellular migration studies demonstrated that the composites support cell viability and migration. The results suggest that PHO/TiO2 composites could be used as novel biomaterials for biomedical applications.
New polyhydroxyoctanoate based composites with incorporated TiO2 microfibers were produced. The presence of the inorganic constituent influenced morphology, physical properties and functionality of the obtained biomaterials. The degree of PHO crystallinity decreased in the composites in a TiO2 concentration dependent manner. The composites were stiffer than the neat PHO, however they preserved their flexibility. Biocompatibility and cellular migration studies showed that composites support cell viability and migration. The obtained results suggest that PHO/TiO2 composites could be used as novel biomaterials with tunable properties for biomedical applications. (C) 2020 Elsevier B.V. All rights reserved.
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