4.5 Article

Myofiber strain in healthy humans using DENSE and cDTI

Journal

MAGNETIC RESONANCE IN MEDICINE
Volume 86, Issue 1, Pages 277-292

Publisher

WILEY
DOI: 10.1002/mrm.28724

Keywords

cDTI; DENSE; myofiber strain

Funding

  1. Hospices Civils de Lyon [69HCL15_744]
  2. National Heart, Lung, and Blood Institute [K25--HL135408, R01--HL131823, R01--HL131975]
  3. American Heart Association [20POST35210644]
  4. Agence Nationale de la Recherche [ANR--16-RHUS-0009]
  5. Agence Nationale de la Recherche (ANR) [ANR-16-RHUS-0009] Funding Source: Agence Nationale de la Recherche (ANR)

Ask authors/readers for more resources

A new efficient pipeline combining microstructural cDTI and functional DENSE data was proposed to measure in vivo myofiber strain in healthy populations within 10 minutes per subject. The study found uniform transmural myofiber strain in healthy volunteers, suggesting its potential as a biomarker for evaluating local cardiomyocyte contractility in assessing cardiovascular dysfunction.
Purpose: Myofiber strain, E-ff, is a mechanistically relevant metric of cardiac cell shortening and is expected to be spatially uniform in healthy populations, making it a prime candidate for the evaluation of local cardiomyocyte contractility. In this study, a new, efficient pipeline was proposed to combine microstructural cDTI and functional DENSE data in order to estimate E-ff in vivo. Methods: Thirty healthy volunteers were scanned with three long-axis (LA) and three short-axis (SA) DENSE slices using 2D displacement encoding and one SA slice of cDTI. The total acquisition time was 11 minutes +/- 3 minutes across volunteers. The pipeline first generates 3D SA displacements from all DENSE slices which are then combined with cDTI data to generate a cine of myofiber orientations and compute E-ff. The precision of the post-processing pipeline was assessed using a computational phantom study. Transmural myofiber strain was compared to circumferential strain, E-cc, in healthy volunteers using a Wilcoxon sign rank test. Results: In vivo, computed E-ff was found uniform transmurally compared to E-cc (-0.14[-0.15, -0.12] vs -0.18 [-0.20, -0.16], P<.001, -0.14 [-0.16, -0.12] vs -0.16 [-0.17, -0.13], P<.001 and -0.14 [-0.16, -0.12] vs E-cc_(C) -0.14 [-0.15, -0.11], P=.002, E-ff_(C) vs E-cc_(C) in the endo, mid, and epi layers, respectively). Conclusion: We demonstrate that it is possible to measure in vivo myofiber strain in a healthy human population in 10 minutes per subject. Myofiber strain was observed to be spatially uniform in healthy volunteers making it a potential biomarker for the evaluation of local cardiomyocyte contractility in assessing cardiovascular dysfunction.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available