Journal
LWT-FOOD SCIENCE AND TECHNOLOGY
Volume 139, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.lwt.2020.110521
Keywords
Antimicrobial activity; Antioxidant activity; Croton betaceus; Croton lundianus; Folk medicine; Hexane fraction
Categories
Funding
- Foundation for the Support of Research and Scientific and Technological Development of Maranhao (FAPEMA)
- FCT-Fundacao para a Ciencia e a Tecnologia, I.P. [PTDC/BII_BIO/31158/2017]
- Fundacao para a Ciencia e Tecnologia (FCT) funds/MCTES (Portugal) [UIDB/50006/2020]
- Fundação para a Ciência e a Tecnologia [PTDC/BII-BIO/31158/2017] Funding Source: FCT
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This study evaluated the antioxidant and antimicrobial potential of ethanol extract and leaf fractions of Croton spp, finding secondary metabolites with biological activities. The extracts and fractions have the potential to inhibit the growth of oral pathogens in different concentrations, with hexane fractions showing high antioxidant power. The fractions of the extracts have important biological activities that can be applied in the development of new antimicrobials for industry and other biotechnological applications.
The growing microbial resistance to antibiotics and the adverse effects of the frequent use of antimicrobials in oral medicine require products as natural therapeutic alternatives. Croton betaceus and C. lundianus can be viable for in-depth studies in search of new biopmducts. This study evaluated the antioxidant and antimicrobial potential of ethanol extract and leaf fractions of Croton spp. The disk diffusion assay, FRAP and DPPH, were used for antimicrobial and antioxidant analysis, respectively. In addition to phytochemical prospecting and toxicity testing. Secondary metabolites with biological activities were found. Researched extracts and fractions have the potential to inhibit the growth of oral pathogens (Gram-positive, Gram-negative and yeast) in different concentrations. Enterococcus faecalis is the most susceptible to the extract. All fractions showed antioxidant potential. The hexane fraction (BHX and LHX) of both species can inhibit the growth of pathogens in low concentrations, and has a high antioxidant power. The fractions of the extracts of C. betaceus and C. lundianus have important biological activities that can be applied in the development of new antimicrobials for industry and other biotechnological applications.
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