Targeting inflammatory cytokine storm to fight against COVID-19 associated severe complications

Such testing and trying time probably never seen before in the human history. The novel coronavirus disease abbreviated as COVID-19 is the ongoing health crisis which entered into human life in late December 2019. The ease of transmission between humans and the undetectability in early stage makes COVID-19 frightening and unprecedented. The disease is characterised by pneumonia progressing to breathing difficulty, acute respiratory distress syndrome (ARDS) and multi-organ failure. Clinical studies suggest excessive release of inflammatory mediators leads to cytokine storm, a phenomenon which appears to be potentially life-threatening in COVID-19. Across the globe, when the world authorities are grappling to contain the virus, our review provides a glimpse on structure, pathophysiology of the virus and further sheds light on various clinical complications associated with the disease in order to open up/raise new horizons to explore various possible theoretical targets for COVID-19. The review also portrays a question and debates: Can targeting cytokine storm can be a feasible approach to combat COVID-19?

Automated summary

COVID-19 is an unprecedented health crisis with its ease of transmission between humans and undetectability in the early stages making it particularly frightening. Characterized by pneumonia progressing to breathing difficulty, acute respiratory distress syndrome, and multi-organ failure, the excessive release of inflammatory mediators leading to cytokine storm is a potentially life-threatening phenomenon associated with this disease.