Journal
JOURNAL OF TRAVEL MEDICINE
Volume 28, Issue 2, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/jtm/taab011
Keywords
COVID-19; mutation; transmission advantage; reproduction number; statistical modelling; B.1.1.7 lineage
Categories
Funding
- CUHK [PIEF/Ph2/COVID/06, 4054456]
- Health and Medical Research Fund (HMRF) Commissioned Research of Hong Kong, China [COVID190103, INF-CUHK-1]
- National Natural Science Foundation of China (NSFC) [31871340, 71974165]
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The N501Y mutation in the UK is rapidly becoming prevalent and poses a major challenge for COVID-19 control. Studies show that this mutation increases the infectivity of the virus by 52%, highlighting the need for increased vigilance and control measures.
The emerging N501Y mutation in severe acute respiratory syndrome coronavirus 2, which becomes prevalent in the UK rapidly, is one of the major challenges of COVID-19 control. To explore the transmission advantage, we estimate that the N501Y substitution increases the infectivity by 52% (95% confidence interval: 46, 58) in terms of the reproduction number.
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