Journal
JOURNAL OF THERMAL BIOLOGY
Volume 96, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtherbio.2020.102827
Keywords
Apoptosis; Heat stress; Oxidative stress; Rat; Royal jelly; Testis
Funding
- Urmia University
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Royal Jelly was found to ameliorate testicular pathologies induced by experimental heat stress in rats by enhancing the testicular antioxidant defense system and regulating germ cells apoptosis.
Testicular heat stress (HS) can lead to testicular tissue destruction and spermatogenesis disturbances. Royal Jelly (RJ) has been introduced as a potent antioxidant. We investigated the effects of RJ on testicular tissue, oxidative stress and sperm apoptosis in HS-exposed rats. Compared to HS-exposed groups, RJ co-treatment could improve testosterone reduction and histopathological damages. The RJ co-administration decreased MDA level in testicular tissue, while TAC and CAT levels were remarkably increased compared to HS-exposed groups. Moreover, significant higher expression level of Bcl-2 and lower expression levels of P53 and Caspase-3 were seen following RJ co-administration compared to HS-exposed groups. Our data suggest that RJ can effectively ameliorate experimental HS-induced testiculopathies in rats through testicular antioxidant defense system restoration and germ cells apoptosis regulation.
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