4.1 Article

Electrochemical approach to trifluoroacetamide synthesis from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) catalyzed by B12 complex

Journal

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
Volume 26, Issue 06N07, Pages 419-426

Publisher

WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S1088424621500292

Keywords

Vitamin B-12; trifluoroacetamide; cobalt complex; catalytic reaction; electrolysis

Funding

  1. Japan Society for the Promotion of Science (JSPS) [JP19H02735]
  2. Nippon Sheet Glass Foundation [HAKF541800]
  3. Cooperative Research Program of Dynamic Alliance for Open Innovation Bridging Human, Environment and Materials [20203024]

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A one-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochemical method with the B-12 complex as a catalyst under mild conditions, in open air at room temperature. Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.
One-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochemical method with the B-12 complex as a catalyst under mild conditions, in open air at room temperature. Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.

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