Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 194, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jpba.2020.113802
Keywords
Surface plasmon resonance; Circulating cancer markers; Biosensors; Liquid biopsy; Body fluids; Validation; ROC curves
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This review article summarizes recent research on surface plasmon resonance biosensors, focusing on their applications in testing cancer markers and discovering new markers.
A review is made of 71 papers on surface plasmon resonance biosensors, published between 2005 and 2020, mostly in the last decade. The reviewed papers are divided into two groups, depending on the validation of the developed biosensor. Validated biosensors are briefly characterized, while those that are not validated are listed in a table. Focus is placed on applications of SPR biosensors in testing the effectiveness of cancer markers and in the discovery of new cancer markers. Seven new markers are proposed, two of them having high sensitivity and diagnostic selectivity as determined by ROC curves. Papers concerning the determination of micro RNA and large particles such as vesicles, exosomes and cancer cells are also reviewed. (C) 2020 Elsevier B.V. All rights reserved.
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