Recent advances in cardiac biomarkers detection: From commercial devices to emerging technologies

Although cardiac pathologies are the major cause of death in the world, it remains difficult to provide a reliable diagnosis to prevent heart attacks. Rapid patient care and management in emergencies are critical to prevent dramatic consequences. Thus, relevant biomarkers such as cardiac troponin and natriuretic peptides are currently targeted by commercialized Point-Of-Care immunoassays. Key points still to be addressed concern cost, lack of standardization, and poor specificity, which could limit the reliability of the assays. Consequently, alternatives are emerging to address these issues. New probe molecules such as aptamers or molecularly imprinted polymers should allow a reduction in cost of the assays and an increase in reproducibility. In addition, the assay specificity and reliability could be improved by enabling multiplexing through the detection of several molecular targets in a single device. (C) 2020 Elsevier B.V. All rights reserved.

Automated summary

Cardiac pathologies remain a major cause of death worldwide, and reliable diagnosis is challenging. Rapid patient care in emergencies is crucial to prevent severe consequences. New probe molecules and multiplexing technologies offer effective alternatives to address the cost and specificity issues in biomarker detection.