Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 5, Pages 3897-3906Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c02764
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Funding
- Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang [2019R01005]
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This method describes a one-pot, four-component annulation to synthesize 2,3,4,6-tetraarylpyridines with high functional group compatibility, solvent-free conditions, and nontoxic byproduct water, providing a simple, economical, and eco-friendly strategy for constructing multiaryl-substituted pyridines.
A one-pot, four-component annulation of 2,3,4,6-tetraarylpyridines from aromatic aldehydes, methyl ketones, diaryl ethanones, and ammonium acetate is described. The reaction features high functional group compatibility in air under solvent-free conditions without any additive and only water as the nontoxic byproduct, providing a strategy for the facile, economical, and ecofriendly construction of multiaryl-substituted pyridines from simple and readily available reactants.
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