Atom-Economical Thiocyanation-Amination of Alkynes with N-Thiocyanato-Dibenzenesulfonimide

A highly regioselective protocol for intermolecular thiocyanation-amination of alkynes by N-thiocyano-dibenzenesulfonimide (NTSI) as the SCN and nitrogen sources has been developed. A C-S bond and C-N bond are simultaneously constructed in only one step. The reaction under simple mild conditions features a broad substrate scope, atom economy, high yields (up to 94%), and excellent functional group tolerance.

Automated summary

A highly regioselective protocol for intermolecular thiocyanation-amination of alkynes using N-thiocyano-dibenzenesulfonimide (NTSI) as the SCN and nitrogen sources has been developed. The reaction features a broad substrate scope, atom economy, high yields (up to 94%), and excellent functional group tolerance under simple mild conditions.