Signaling mechanisms underlying inhibition of neuroinflammation by resveratrol in neurodegenerative diseases

Neurodegenerative diseases (NDs), including Alzheimer's disease (AD), and Parkinson's disease (PD), are characterized by the progressive loss of the structure and function of neurons and most commonly occur in the elderly population. Microglia are resident macrophages of the central nervous system (CNS). The neuroinflammation caused by excessive microglial activation is closely related to the onset and progression of many NDs. Therefore, inhibiting excessive microglial activation is a potential drug target for controlling neuroinflammation. In recent years, natural products as modulators of microglial polarization have attracted considerable attention in the field of NDs therapy. Furthermore, resveratrol (RES) has been found to have a protective effect in NDs through the inhibition of microglial activation and the regulation of neuroinflammation. In this review, we mainly summarize the therapeutic potential of RES and its various molecular mechanisms in the treatment of NDs through the modulation of microglial activation. (c) 2020 Elsevier Inc. All rights reserved.

Automated summary

Neurodegenerative diseases, such as Alzheimer's and Parkinson's, involve progressive loss of neurons and are common in the elderly. Excessive microglial activation leading to neuroinflammation is closely linked to the onset and progression of these diseases. Natural products like resveratrol show therapeutic potential in modulating microglial polarization and controlling neuroinflammation in the treatment of NDs.