Journal
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume 89, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2020.108556
Keywords
L-theanine; prostate cancer; metastasis; MMP9; Snail
Funding
- Natural Science Foundation of China [81671565, 81771703, 31571166]
- Priority Academic Program Development of Jiangsu Higher Education Institution (PADD)
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L-theanine has been shown to inhibit invasion and migration of prostate cancer cells, as well as increase cell-cell adhesion. It also suppresses the epithelial-mesenchymal transition process in PCa. Through downregulating certain proteins and inhibiting specific signaling pathways, L-theanine shows therapeutic potential for metastatic prostate cancer.
Prostate cancer (PCa) is a very prevalent male-specific malignancy; most PCa patients eventually die as a result of metastasis. L-theanine (C7H14N2O3), a nonprotein amino acid derivative from green tea leaves, has been demonstrated to act as an anticarcinogen through proapoptotic and antiproliferative effects. However, the antimetastatic effect of L-theanine in tumor cells and its underlying mechanism are still unclear. Here, we found that L-theanine could suppress invasion, migration, and increase cell-cell adhesion of prostate cancer cells in vitro and in vivo . We also found that L-theanine could inhibit the epithelial-mesenchymal transition process in PCa. Our study revealed that L-theanine could downregulate MMP9, N-cadherin, Vimentin, Snail, and upregulate E-cadherin. Furthermore, L-theanine suppressed the transcription of MMP9 and Snail by significantly inhibiting the ERK/NF-KB signaling pathway and the binding activity of p65 to the promoter regions of MMP9 and Snail. All of these findings suggest that L-theanine has therapeutic potential for metastatic PCa and may be considered a promising candidate for antimetastatic therapy of prostate cancer. (c) 2020 Elsevier Inc. All rights reserved. Superscript/Subscript Available
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