Journal
JOURNAL OF NATURAL PRODUCTS
Volume 84, Issue 3, Pages 562-569Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.0c01121
Keywords
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Funding
- National Research Foundation of Korea (NRF) - Korea government (MIST) [2020R1A2C1008406]
- Korea Basic Science Institute under the RD program [C140440]
- National Research Council of Science & Technology (NST), Republic of Korea [C140440] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2020R1A2C1008406] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Three new guaianolide lactones and four new 9-oxonerolidol glucosides were isolated from the flowers of Chrysanthemum indicum. Some of these compounds showed inhibitory effects on nitric oxide production in cells, indicating their potential pharmacological activities.
Three new guaianolide lactones (1-3) and four new 9-oxonerolidol glucosides (5-8) together with 20 known compounds were isolated from the MeOH extract of the flowers of Chrysanthemum indicum. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data along with acid hydrolysis. Of the isolates, sesquiterpenoids 1-4 and 15 and flavones 17 and 18 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 cells with IC50 values in the range 0.2-27.0 mu M.
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