Journal
JOURNAL OF NATURAL PRODUCTS
Volume 84, Issue 2, Pages 537-543Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.0c01243
Keywords
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Funding
- National Natural Science Foundation of China [81773556, 81903676]
- Science and Technology Department of Guangdong Province of China [2015A020211010]
- Southern Medical University [B1040903]
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A new bafilomycin derivative and known bafilomycins isolated from Streptomyces sp. HTL16 showed potent antiviral activities against influenza A and SARS-CoV-2 viruses by inhibiting endosomal ATP-driven proton pumps, with IC50 values in the nanomolar range.
A new bafilomycin derivative (1) and another seven known bafilomycins (2-8) were isolated from feces-derived Streptomyces sp. HTL16. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent antiviral activities against the influenza A and SARS-CoV-2 viruses, with IC50 values in the nanomolar range, by inhibiting the activity of endosomal ATP-driven proton pumps.
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