4.7 Article

Selaginellin Derivatives from Selaginella tamariscina and Their Upregulating Effects on Low-Density Lipoprotein Receptor Expression

Journal

JOURNAL OF NATURAL PRODUCTS
Volume 84, Issue 3, Pages 857-864

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.0c01123

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Funding

  1. National Research Foundation of Korea (NRF) - Korean government (MSIT) [NRF-2019R1A2C2009053]

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Several new compounds were isolated from Selaginella tamariscina, including a novel derivative, selapiginellin A, and a known compound, diselaginellin A. Selaginpulvilin U was found to regulate the mRNA expression of the LDLR gene.
Two new dimeric selaginellins, diselaginellins C and D (1 and 2), a new unusual derivative, selapiginellin A (4), a new selaginpulvilin U (5), and a known derivative, diselaginellin A (3), were isolated from Selaginella tamariscina (P. Beauv.) Spring. Among these compounds, selapiginellin A (4) is the first naturally occurring compound comprising an ether-linked dimer of a selaginellin and a selaginpulvilin. The absolute configurations of 1, 2, and 4 were elucidated by spectroscopic data analyses. Compound 5 was found to regulate mRNA expression of the low-density lipoprotein receptor (LDLR) gene and LDLR-related genes.

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