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HUMAN MOLECULAR GENETICS (2014)
Phase II trial of panobinostat, an oral pan-deacetylase inhibitor in patients with primary myelofibrosis, post-essential thrombocythaemia, and post-polycythaemia vera myelofibrosis
Daniel J. DeAngelo et al.
BRITISH JOURNAL OF HAEMATOLOGY (2013)
Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group
Mercedes Lobera et al.
NATURE CHEMICAL BIOLOGY (2013)
Development of a histone deacetylase 6 inhibitor and its biological effects
Ju-Hee Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors
Timothy Forsyth et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma
Loredana Santo et al.
BLOOD (2012)
The Synergistic Effects of DNA-Targeted Chemotherapeutics and Histone Deacetylase Inhibitors As Therapeutic Strategies for Cancer Treatment
M. Stiborova et al.
CURRENT MEDICINAL CHEMISTRY (2012)
Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini
Hui Ouyang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Structural Basis for Sirtuin Activity and Inhibition
Hua Yuan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Selective Histone Deacetylase 6 Inhibitors Bearing Substituted Urea Linkers Inhibit Melanoma Cell Growth
Joel A. Bergman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors
Eunhyun Choi et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
The Role of HDAC6 in Cancer
Grace I. Aldana-Masangkay et al.
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2011)
Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a Potent Janus Kinase 2/Fms-Like Tyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment of Myelofibrosis and Lymphoma
Anthony D. William et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Histone deacetylases as regulators of inflammation and immunity
Melanie R. Shakespear et al.
TRENDS IN IMMUNOLOGY (2011)
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms
Alfonso Quintas-Cardama et al.
BLOOD (2010)
Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A
Kyle V. Butler et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Regulation of Cellular Metabolism by Protein Lysine Acetylation
Shimin Zhao et al.
SCIENCE (2010)
Dynamic DNA Methylation
Julie A. Law et al.
SCIENCE (2009)
Traversing the coordination chemistry and chemical biology of hydroxamic acids
Rachel Codd
COORDINATION CHEMISTRY REVIEWS (2008)
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: A new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6
Alan P. Kozikowski et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs
Kouji Hirota et al.
NATURE (2008)
HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation
R. B. Parmigiani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
HDAC6 modulates cell motility by altering the acetylation level of cortactin
Xiaohong Zhang et al.
MOLECULAR CELL (2007)
Epigenetics: A landscape takes shape
Aaron D. Goldberg et al.
CELL (2007)
Chromatin modifications and their function
Tony Kouzarides
CELL (2007)
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma, (CTCL)
Madeleine Duvic et al.
BLOOD (2007)
Synthesis, enzymatic inhibition, and cancer cell growth inhibition of novel δ-lactam-based histone deacetylase (HDAC) inhibitors
Hwan Mook Kim et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Targeting histone deacetylase in cancer therapy
Hsiang-Yu Lin et al.
MEDICINAL RESEARCH REVIEWS (2006)
Synthesis and evaluation of estrogen receptor ligands with bridged oxabicyclic cores containing a diarylethylene motif: Estrogen antagonists of unusual structure
HB Zhou et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
JJ Kovacs et al.
MOLECULAR CELL (2005)
Hydroxamic acids - An intriguing family of enzyme inhibitors and biomedical ligands
CJ Marmion et al.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2004)
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor
A Vannini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The Janus kinases (Jaks)
K Yamaoka et al.
GENOME BIOLOGY (2004)
Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 1. Receptor interactions
VC Jordan
JOURNAL OF MEDICINAL CHEMISTRY (2003)
HDAC6 is a microtubule-associated deacetylase
C Hubbert et al.
NATURE (2002)
Histone deacetylase as a new target for cancer chemotherapy
M Yoshida et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2001)
Janus kinases: components of multiple signaling pathways
SG Rane et al.
ONCOGENE (2000)
Design and synthesis of piperazine-based matrix metalloproteinase inhibitors
MY Cheng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)