Related references
Note: Only part of the references are listed.AXL Inhibition Induces DNA Damage and Replication Stress in Non-Small Cell Lung Cancer Cells and Promotes Sensitivity to ATR Inhibitors
Kavya Ramkumar et al.
MOLECULAR CANCER RESEARCH (2021)
JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
Justin Stebbing et al.
SCIENCE ADVANCES (2021)
Receptor tyrosine kinase inhibitors block proliferation of TGEV mainly through p38 mitogen-activated protein kinase pathways
Wanyu Dong et al.
ANTIVIRAL RESEARCH (2020)
Structure-activity relationship study of the pyridine moiety of isothiazolo[4, 3-b]pyridines as antiviral agents targeting cyclin G-associated kinase
Belen Martinez-Gualda et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2020)
Sphingosine kinase-2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl-1
Francis R. LeBlanc et al.
BRITISH JOURNAL OF HAEMATOLOGY (2020)
Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections
Wei-Chia Chen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Baricitinib as potential treatment for 2019-nCoV acute respiratory disease
Peter Richardson et al.
LANCET (2020)
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
Roujian Lu et al.
LANCET (2020)
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang et al.
LANCET (2020)
COVID-19: combining antiviral and anti-inflammatory treatments
Justin Stebbing et al.
LANCET INFECTIOUS DISEASES (2020)
BX795 demonstrates potent antiviral benefits against herpes simplex Virus-1 infection of human cell lines
Aqsa Iqbal et al.
ANTIVIRAL RESEARCH (2020)
The BTK inhibitor ibrutinib may protect against pulmonary injury in COVID-19-infected patients
Steven P. Treon et al.
BLOOD (2020)
BTK Inhibitors in Cancer Patients with COVID-19: The Winner Will be the One Who Controls That Chaos (Napoleon Bonaparte)
Elise A. Chong et al.
CLINICAL CANCER RESEARCH (2020)
Critical Assessment of Pharmacokinetic Drug-Drug Interaction Potential of Tofacitinib, Baricitinib and Upadacitinib, the Three Approved Janus Kinase Inhibitors for Rheumatoid Arthritis Treatment
Vijayabhaskar Veeravalli et al.
DRUG SAFETY (2020)
Mechanism of baricitinib supports artificial intelligence-predicted testing inCOVID-19 patients
Justin Stebbing et al.
EMBO MOLECULAR MEDICINE (2020)
JAK Inhibition as a New Treatment Strategy for Patients with COVID-19
Farhad Seif et al.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2020)
Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial
Yang Cao et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)
Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact
Fabrizio Cantini et al.
JOURNAL OF INFECTION (2020)
TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib
Dandan Wu et al.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION (2020)
Potential Drugs Targeting Early Innate Immune Evasion of SARS-Coronavirus 2 via 2'-O-Methylation of Viral RNA
Jose Antonio Encinar et al.
VIRUSES-BASEL (2020)
Reply: Potential role of Janus kinase inhibitors in COVID-19
Maddalena Napolitano et al.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)
Drug repurposing of pyrimidine analogs as potent antiviral compounds against human enterovirus A71 infection with potential clinical applications
Jialei Sun et al.
SCIENTIFIC REPORTS (2020)
COVID-19: consider cytokine storm syndromes and immunosuppression
Puja Mehta et al.
LANCET (2020)
Immunomodulation in COVID-19
Nicholas E. Ingraham et al.
LANCET RESPIRATORY MEDICINE (2020)
Incidence of venous and arterial thromboembolic events reported in the tofacitinib rheumatoid arthritis, psoriasis and psoriatic arthritis development programmes and from real-world data
Philip Mease et al.
ANNALS OF THE RHEUMATIC DISEASES (2020)
In Vitro and In Vivo Activity, Tolerability, and Mechanism of Action of BX795 as an Antiviral against Herpes Simplex Virus 2 Genital Infection
James Hopkins et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)
Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse model
Martin Laure et al.
ANTIVIRAL RESEARCH (2020)
Kinase inhibitor roscovitine as a PB2 cap-binding inhibitor against influenza a virus replication
Qi Huang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)
A77 1726, the active metabolite of the anti-rheumatoid arthritis drug leflunomide, inhibits influenza A virus replication in vitro and in vivo by inhibiting the activity of Janus kinases
Jiongjiong Wang et al.
FASEB JOURNAL (2020)
Inhibition of Bruton tyrosine kinase in patients with severe COVID-19
Mark Roschewski et al.
SCIENCE IMMUNOLOGY (2020)
Ruxolitinib Rapidly Reduces Acute Respiratory Distress Syndrome in COVID-19 Disease. Analysis of Data Collection From RESPIRE Protocol
Enrico Capochiani et al.
FRONTIERS IN MEDICINE (2020)
The use of Janus kinase inhibitors in the time of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Danielle Peterson et al.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)
The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19 with severe systemic hyperinflammation
F. La Rosee et al.
LEUKEMIA (2020)
Repurposing of Kinase Inhibitors for Treatment of COVID-19
Ellen Weisberg et al.
PHARMACEUTICAL RESEARCH (2020)
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2
Yuan-Lin Kang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19
Wei Luo et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2020)
ACCORD: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalised Patients: A structured summary of a study protocol for a randomised controlled trial
Tom Wilkinson et al.
TRIALS (2020)
Filgotinib suppresses HIV-1-driven gene transcription by inhibiting HIV-1 splicing and T cell activation
Yang-Hui Jimmy Yeh et al.
JOURNAL OF CLINICAL INVESTIGATION (2020)
Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients
Irma Convertino et al.
CRITICAL CARE (2020)
Lessons learned from SARS-CoV and MERS-CoV: FDA-approved Abelson tyrosine-protein kinase 2 inhibitors may help us combat SARS-CoV-2
Seyed Fazel Nabavi et al.
ARCHIVES OF MEDICAL SCIENCE (2020)
Combination therapy of rabies-infected mice with inhibitors of pro-inflammatory host response, antiviral compounds and human rabies immunoglobulin
Andras Marosi et al.
VACCINE (2019)
Evaluation of in vitro inhibitory potential of type-I interferons and different antiviral compounds on rabies virus replication
Andras Marosi et al.
VACCINE (2019)
Safety Profile of Baricitinib in Patients with Active Rheumatoid Arthritis with over 2 Years Median Time in Treatment
Josef S. Smolen et al.
JOURNAL OF RHEUMATOLOGY (2019)
Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs
Rebecca Broeckel et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2019)
Influenza Virus Infections and Cellular Kinases
Robert Meineke et al.
VIRUSES-BASEL (2019)
RNAi-based small molecule repositioning reveals clinically approved urea-based kinase inhibitors as broadly active antivirals
Markus Lesch et al.
PLOS PATHOGENS (2019)
Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3-b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity
Sven Verdonck et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Aurora kinase A promotes hepatitis B virus replication and expression
Gi Uk Jeong et al.
ANTIVIRAL RESEARCH (2019)
Filgotinib, a JAK1 Inhibitor, for Treatment-Resistant Rheumatoid Arthritis
Jasvinder A. Singh
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)
Genistein Has Antiviral Activity against Herpes B Virus and Acts Synergistically with Antiviral Treatments to Reduce Effective Dose
Julia C. LeCher et al.
VIRUSES-BASEL (2019)
Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells
Daniel P. Strange et al.
MBIO (2019)
Dual effect of the broad spectrum kinase inhibitor midostaurin in acute and latent HIV-1 infection
Edurne Garcia-Vidal et al.
ANTIVIRAL RESEARCH (2019)
Kinase inhibitors tyrphostin 9 and rottlerin block early steps of rabies virus cycle
Zoe Lama et al.
ANTIVIRAL RESEARCH (2019)
Targeting the proviral host kinase, FAK, limits influenza a virus pathogenesis and NFkB-regulated pro-inflammatory responses
Silke Bergmann et al.
VIROLOGY (2019)
Src Tyrosine Kinase Inhibitors: New Perspectives on Their Immune, Antiviral, and Senotherapeutic Potential
Jose Rivera-Torres et al.
FRONTIERS IN PHARMACOLOGY (2019)
An Influenza Virus Entry Inhibitor Targets Class II PI3 Kinase and Synergizes with Oseltamivir
Ryan O'Hanlon et al.
ACS INFECTIOUS DISEASES (2019)
Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro
Anika Grafen et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)
The efficacy of a cyclin dependent kinase 9 (CDK9) inhibitor, FIT039, on verruca vulgaris: study protocol for a randomized controlled trial
Takashi Nomura et al.
TRIALS (2019)
Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells
Chang Liu et al.
CELLS (2019)
Virtual screening identified compounds that bind to cyclin dependent kinase 2 and prevent herpes simplex virus type 1 replication and reactivation in neurons
Daiane J. Viegas et al.
ANTIVIRAL RESEARCH (2019)
Safety and efficacy of tofacitinib for up to 9.5years in the treatment of rheumatoid arthritis: final results of a global, open-label, long-term extension study
Juergen Wollenhaupt et al.
ARTHRITIS RESEARCH & THERAPY (2019)
Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations
Iain B. McInnes et al.
ARTHRITIS RESEARCH & THERAPY (2019)
Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment
Szu-Yuan Pu et al.
ANTIVIRAL RESEARCH (2018)
Repurposed FDA-Approved drug sorafenib reduces replication of Venezuelan equine encephalitis virus and other alphaviruses
Lindsay Lundberg et al.
ANTIVIRAL RESEARCH (2018)
The clinically approved MEK inhibitor Trametinib efficiently blocks influenza A virus propagation and cytokine expression
Tobias Schraeder et al.
ANTIVIRAL RESEARCH (2018)
CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia
Masahiko Ajiro et al.
CLINICAL CANCER RESEARCH (2018)
Repurposing of Kinase Inhibitors as Broad-Spectrum Antiviral Drugs
Stanford Schor et al.
DNA AND CELL BIOLOGY (2018)
PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases
Leen Delang et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2018)
Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication
Grant R. Campbell et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors
Jeanne M. Sisk et al.
JOURNAL OF GENERAL VIROLOGY (2018)
Antiviral activity of A771726, the active metabolite of leflunomide, against Junin virus
Claudia S. Sepulveda et al.
JOURNAL OF MEDICAL VIROLOGY (2018)
Optimization of Isothiazolo[4,3-b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity
Szu-Yuan Pu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Ebola virus requires phosphatidylinositol (3,5) bisphosphate production for efficient viral entry
Shirley Qiu et al.
VIROLOGY (2018)
Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro
Jin Soo Shin et al.
VIRUSES-BASEL (2018)
Antiviral activity of ginsenoside Rg3 isomers against gammaherpesvirus through inhibition of p38-and JNK-associated pathways
Soowon Kang et al.
JOURNAL OF FUNCTIONAL FOODS (2018)
Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release
Fei Xiao et al.
MBIO (2018)
Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice
Chuan Xia et al.
ANTIVIRAL RESEARCH (2018)
Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target
Emilio Yanguez et al.
NATURE COMMUNICATIONS (2018)
The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus infected A129 mice: A host-targeting treatment strategy
Jasper Fuk-Woo Chan et al.
ANTIVIRAL RESEARCH (2018)
FLT3 inhibitors in acute myeloid leukemia
Mei Wu et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)
Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology
Ivana Mejdrova et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Tyrosine kinase inhibitors: potential use and safety considerations in HIV-1 infection
Mayte Coiras et al.
EXPERT OPINION ON DRUG SAFETY (2017)
Chemical Genomics Approach Leads to the Identification of Hesperadin, an Aurora B Kinase Inhibitor, as a Broad-Spectrum Influenza Antiviral
Yanmei Hu et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
Inhibition of MEK-ERK1/2-MAP kinase signalling pathway reduces rabies virus induced pathologies in mouse model
Venkataravanappa Manjunatha et al.
MICROBIAL PATHOGENESIS (2017)
Viral infections: Targeting host kinases
Crunkhorn Sarah
NATURE REVIEWS DRUG DISCOVERY (2017)
Combination of Leflunomide and Everolimus for treatment of BK virus nephropathy
Juli Jaw et al.
NEPHROLOGY (2017)
Identification of Polo-like kinases as potential novel drug targets for influenza A virus
Marie O. Pohl et al.
SCIENTIFIC REPORTS (2017)
Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus
Keiko Rausch et al.
CELL REPORTS (2017)
Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses
Laurent Meertens et al.
CELL REPORTS (2017)
The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection
Elizabeth A. Nelson et al.
PLOS NEGLECTED TROPICAL DISEASES (2017)
Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors
Christina Gavegnano et al.
PLOS PATHOGENS (2017)
A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors
Carolyn D. Britten et al.
CLINICAL CANCER RESEARCH (2017)
R00504985 is an inhibitor of CMGC kinase proteins and has anti-human cytomegalovirus activity
Blair L. Strang
ANTIVIRAL RESEARCH (2017)
Midostaurin, a Novel Protein Kinase Inhibitor for the Treatment of Acute Myelogenous Leukemia: Insights from Human Absorption, Metabolism, and Excretion Studies of a BDDCS II Drug
Handan He et al.
DRUG METABOLISM AND DISPOSITION (2017)
The MEK-inhibitor CI-1040 displays a broad anti-influenza virus activity in vitro and provides a prolonged treatment window compared to standard of care in vivo
Emanuel Haasbach et al.
ANTIVIRAL RESEARCH (2017)
Comparison of three cell-based drug screening platforms for HSV-1 infection
Leonardo D'Aiuto et al.
ANTIVIRAL RESEARCH (2017)
Antiviral activity of PHA767491 against human herpes simplex virus in vitro and in vivo
Jue Hou et al.
BMC INFECTIOUS DISEASES (2017)
Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1
Roger Badia et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2016)
The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis
Kristy Koselny et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)
Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation
Tomohisa Tanaka et al.
ANTIVIRAL RESEARCH (2016)
Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion
Christopher M. Coleman et al.
JOURNAL OF VIROLOGY (2016)
Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
Miao Xu et al.
NATURE MEDICINE (2016)
The Janus kinase inhibitor ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model
Woldeab B. Haile et al.
NEUROBIOLOGY OF DISEASE (2016)
JNK and p38 mitogen-activated protein kinase pathways contribute to porcine epidemic diarrhea virus infection
Changhee Lee et al.
VIRUS RESEARCH (2016)
Identification and characterization of the role of c-terminal Src kinase in dengue virus replication
Rinki Kumar et al.
SCIENTIFIC REPORTS (2016)
GNF-2 Inhibits Dengue Virus by Targeting Abl Kinases and the Viral E Protein
Margaret J. Clark et al.
CELL CHEMICAL BIOLOGY (2016)
A Novel CDK7 Inhibitor of the Pyrazolotriazine Class Exerts Broad-Spectrum Antiviral Activity at Nanomolar Concentrations
Corina Hutterer et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Inhibitors of cellular kinases with broad-spectrum antiviral activity for hemorrhagic fever viruses
Emma L. Mohr et al.
ANTIVIRAL RESEARCH (2015)
Repurposing Kinase Inhibitors as Antiviral Agents to Control Influenza A Virus Replication
Olivia Perwitasari et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2015)
Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents
Sona Kovackova et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action
Ivana Mejdrova et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Combating emerging viral threats
Elena Bekerman et al.
SCIENCE (2015)
Isothiazolo[4,3-b]pyridines as inhibitors of cyclin G associated kinase: synthesis, structure-activity relationship studies and antiviral activity
Jiahong Li et al.
MEDCHEMCOMM (2015)
Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus
Cristina M. Dorobantu et al.
PLOS PATHOGENS (2015)
Repurposing FDA-approved drugs as therapeutics to treat Rift Valley fever virus infection
Ashwini Benedict et al.
FRONTIERS IN MICROBIOLOGY (2015)
Antiviral Potential of ERK/MAPK and PI3K/AKT/mTOR Signaling Modulation for Middle East Respiratory Syndrome Coronavirus Infection as Identified by Temporal Kinome Analysis
Jason Kindrachuk et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C
Fei Xiao et al.
GUT (2015)
Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity
Eduardo Pauls et al.
AIDS (2014)
Akt Inhibitor MK2206 Prevents Influenza pH1N1 Virus Infection In Vitro
Oxana V. Denisova et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection
Julie Dyall et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Ruxolitinib and Tofacitinib Are Potent and Selective Inhibitors of HIV-1 Replication and Virus Reactivation In Vitro
Christina Gavegnano et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
MEK/ERK activation plays a decisive role in yellow fever virus replication: Implication as an antiviral therapeutic target
Jonas D. Albarnaz et al.
ANTIVIRAL RESEARCH (2014)
The multi-targeted kinase inhibitor sorafenib inhibits enterovirus 71 replication by regulating IRES-dependent translation of viral proteins
Meng Gao et al.
ANTIVIRAL RESEARCH (2014)
Identification of a novel multiple kinase inhibitor with potent antiviral activity against influenza virus by reducing viral polymerase activity
Yutaka Sasaki et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
Dinaciclib for the treatment of breast cancer
Carmen Criscitiello et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2014)
CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses
Makoto Yamamoto et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Phase II Trial of Imatinib in AIDS-Associated Kaposi's Sarcoma: AIDS Malignancy Consortium Protocol 042
Henry B. Koon et al.
JOURNAL OF CLINICAL ONCOLOGY (2014)
Raf/MEK/ERK pathway activation is required for Junin virus replication
Maria Eugenia Rodriguez et al.
JOURNAL OF GENERAL VIROLOGY (2014)
Cell Cycle Control and HIV-1 Susceptibility Are Linked by CDK6-Dependent CDK2 Phosphorylation of SAMHD1 in Myeloid and Lymphoid Cells
Eduardo Pauls et al.
JOURNAL OF IMMUNOLOGY (2014)
Modulation of PI3K-LXRα-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin
Sandra Pisonero-Vaquero et al.
LABORATORY INVESTIGATION (2014)
Preclinical to Clinical Translation of Tofacitinib, a Janus Kinase Inhibitor, in Rheumatoid Arthritis
Martin E. Dowty et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)
Inhibition of Influenza A Virus Infection in Vitro by Saliphenylhalamide-Loaded Porous Silicon Nanoparticles
Luis M. Bimbo et al.
ACS NANO (2013)
Combination of MEK inhibitors and oseltamivir leads to synergistic antiviral effects after influenza A virus infection in vitro
Emanuel Haasbach et al.
ANTIVIRAL RESEARCH (2013)
Development of cellular signaling pathway inhibitors as new antivirals against influenza
Oliver Planz
ANTIVIRAL RESEARCH (2013)
Interaction of Hepatitis C Virus Core Protein with Janus Kinase Is Required for Efficient Production of Infectious Viruses
Choongho Lee
BIOMOLECULES & THERAPEUTICS (2013)
Effector Kinase Coupling Enables High-Throughput Screens for Direct HIV-1 Nef Antagonists with Antiretroviral Activity
Lori A. Emert-Sedlak et al.
CHEMISTRY & BIOLOGY (2013)
PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling
Xinming Cai et al.
CHEMISTRY & BIOLOGY (2013)
Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases
Luc Van Rompaey et al.
JOURNAL OF IMMUNOLOGY (2013)
The Small Molecules AZD0530 and Dasatinib Inhibit Dengue Virus RNA Replication via Fyn Kinase
Melissanne de Wispelaere et al.
JOURNAL OF VIROLOGY (2013)
Leflunomide therapy for BK virus allograft nephropathy after pediatric kidney transplantation
Young H. Jung et al.
PEDIATRIC TRANSPLANTATION (2013)
Identification of Novel Compounds Inhibiting Chikungunya Virus-Induced Cell Death by High Throughput Screening of a Kinase Inhibitor Library
Deu John M. Cruz et al.
PLOS NEGLECTED TROPICAL DISEASES (2013)
High Content Screening of a Kinase-Focused Library Reveals Compounds Broadly-Active against Dengue Viruses
Deu John M. Cruz et al.
PLOS NEGLECTED TROPICAL DISEASES (2013)
A phase IIa, randomized, double-blind, placebo-controlled trial of apilimod mesylate, an interleukin-12/interleukin-23 inhibitor, in patients with rheumatoid arthritis
Sarah Krausz et al.
ARTHRITIS AND RHEUMATISM (2012)
Nilotinib preclinical pharmacokinetics and practical application toward clinical projections of oral absorption and systemic availability
Binfeng Xia et al.
BIOPHARMACEUTICS & DRUG DISPOSITION (2012)
The TIM and TAM Families of Phosphatidylserine Receptors Mediate Dengue Virus Entry
Laurent Meertens et al.
CELL HOST & MICROBE (2012)
The Cyclin-Dependent Kinase Inhibitor Flavopiridol Potentiates Doxorubicin Efficacy in Advanced Sarcomas: Preclinical Investigations and Results of a Phase I Dose-Escalation Clinical Trial
Jason J. Luke et al.
CLINICAL CANCER RESEARCH (2012)
AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B-cell lymphomas
Wenqing Qi et al.
INTERNATIONAL JOURNAL OF CANCER (2012)
Distinct Effects of Saracatinib on Memory CD8+ T Cell Differentiation
Shinji Takai et al.
JOURNAL OF IMMUNOLOGY (2012)
Activation of the Ras/Raf/MEK Pathway Facilitates Hepatitis C Virus Replication via Attenuation of the Interferon-JAK-STAT Pathway
Qi Zhang et al.
JOURNAL OF VIROLOGY (2012)
The PI3K/Akt Pathway Contributes to Arenavirus Budding
Shuzo Urata et al.
JOURNAL OF VIROLOGY (2012)
Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor
Mustapha Haddach et al.
ACS MEDICINAL CHEMISTRY LETTERS (2012)
Identification and Targeting of an Interaction between a Tyrosine Motif within Hepatitis C Virus Core Protein and AP2M1 Essential for Viral Assembly
Gregory Neveu et al.
PLOS PATHOGENS (2012)
Inhibition of poxvirus spreading by the anti-tumor drug Gefitinib (Iressa (TM))
Stefan Langhammer et al.
ANTIVIRAL RESEARCH (2011)
Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo
Karoline Droebner et al.
ANTIVIRAL RESEARCH (2011)
Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS5A Is Essential for Integrity of the Membranous Replication Compartment
Simon Reiss et al.
CELL HOST & MICROBE (2011)
Novel, Selective CDK9 Inhibitors for the Treatment of HIV Infection
G. Nemeth et al.
CURRENT MEDICINAL CHEMISTRY (2011)
The Pharmacokinetics, Pharmacodynamics, and Safety of Orally Dosed INCB018424 Phosphate in Healthy Volunteers
Jack G. Shi et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2011)
Variola and Monkeypox Viruses Utilize Conserved Mechanisms of Virion Motility and Release That Depend on Abl and Src Family Tyrosine Kinases
Patrick M. Reeves et al.
JOURNAL OF VIROLOGY (2011)
Chikungunya Virus Induces IPS-1-Dependent Innate Immune Activation and Protein Kinase R-Independent Translational Shutoff
Laura K. White et al.
JOURNAL OF VIROLOGY (2011)
Blocking eIF4E-eIF4G Interaction as a Strategy To Impair Coronavirus Replication
Regina Cencic et al.
JOURNAL OF VIROLOGY (2011)
Receptor Tyrosine Kinase Inhibitors Block Multiple Steps of Influenza A Virus Replication
Naveen Kumar et al.
JOURNAL OF VIROLOGY (2011)
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy
Joachim Lupberger et al.
NATURE MEDICINE (2011)
Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia
S. Hart et al.
BLOOD CANCER JOURNAL (2011)
High-Content Assay to Identify Inhibitors of Dengue Virus Infection
David Shum et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2010)
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms
Alfonso Quintas-Cardama et al.
BLOOD (2010)
Metabolism, Excretion, and Pharmacokinetics of [14C]INCB018424, a Selective Janus Tyrosine Kinase 1/2 Inhibitor, in Humans
Adam D. Shilling et al.
DRUG METABOLISM AND DISPOSITION (2010)
Randomized, Double-Blind, Placebo-Controlled Trial of the Oral Interleukin-12/23 Inhibitor Apilimod Mesylate for Treatment of Active Crohn's Disease
Bruce E. Sands et al.
INFLAMMATORY BOWEL DISEASES (2010)
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors
Jianming Zhang et al.
NATURE (2010)
Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6
Melodie L. Weller et al.
NATURE MEDICINE (2010)
Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis.
Srdan Verstovsek et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Anti-BK Virus Mechanisms of Sirolimus and Leflunomide Alone and in Combination: Toward a New Therapy for BK Virus Infection
Abdelhamid Liacini et al.
TRANSPLANTATION (2010)
Inhibition of human immunodeficiency virus type-1 by cdk inhibitors
Irene Guendel et al.
AIDS RESEARCH AND THERAPY (2010)
Chemical Library Screens Targeting an HIV-1 Accessory factor/Host Cell Kinase Complex Identify Novel Antiretroviral Compounds
Lori Emert-Sedlak et al.
ACS CHEMICAL BIOLOGY (2009)
Identification of Novel Cellular Targets for Therapeutic Intervention Against Ebola Virus Infection by siRNA Screening
Andrey A. Kolokoltsov et al.
DRUG DEVELOPMENT RESEARCH (2009)
Seliciclib in malignancies
Ibrahim T. Aldoss et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)
New aspects of an anti-tumour drug: sorafenib efficiently inhibits HCV replication
K. Himmelsbach et al.
GUT (2009)
Participation of the phosphatidylinositol 3-kinase/Akt pathway in Junin virus replication in vitro
F. N. Linero et al.
VIRUS RESEARCH (2009)
Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: Involvement of p38 MAPK and ERK
Masakazu Kono et al.
ANTIVIRAL RESEARCH (2008)
Genistein treatment of cells inhibits arenavirus infection
Eric M. Vela et al.
ANTIVIRAL RESEARCH (2008)
Role of cdk9 in the Optimization of Expression of the Genes Regulated by ICP22 of Herpes Simplex Virus 1
Lizette Olga Durand et al.
JOURNAL OF VIROLOGY (2008)
Phosphoinositide-3 kinase-Akt pathway controls cellular entry of Ebola virus
Mohammad F. Saeed et al.
PLOS PATHOGENS (2008)
Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening
Lubica Supekova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Discovery and preclinical characterization of INCB018424, a selective JAK2 inhibitor for the treatment of myeloproliferative disorders
Jordan Fridman et al.
BLOOD (2007)
The ERK mitogen-activated protein kinase pathway contributes to Ebola virus glycoprotein-induced cytotoxicity
Carisa A. Zampieri et al.
JOURNAL OF VIROLOGY (2007)
The tyrosine kinase inhibitor genistein blocks HIV-1 infection in primary human macrophages
Tzanko S. Stantchev et al.
VIRUS RESEARCH (2007)
Raf-1 kinase associates with Hepatitis C virus NS5A and regulates viral replication
T Bürckstümmer et al.
FEBS LETTERS (2006)
Down-regulation of the tumor suppressor gene C-terminal Src kinase: An early event during premalignant colonic epithelial hyperproliferation
DP Kunte et al.
FEBS LETTERS (2005)
Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases
PM Reeves et al.
NATURE MEDICINE (2005)
Leflunomide for polyomavirus type BK nephropathy
JW Williams et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Imatinib-induced regression of AIDS-related Kaposi's sarcoma
HB Koon et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Clathrin- and caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolae
EM Damm et al.
JOURNAL OF CELL BIOLOGY (2005)
Antiviral activity of CYC202 in HIV-1-infected cells
E Agbottah et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
MEK inhibition impairs influenza B virus propagation without emergence of resistant variants
S Ludwig et al.
FEBS LETTERS (2004)
Viral and cellular kinases are potential antiviral targets and have a central role in varicella zoster virus pathogenesis
JF Moffat et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2004)
Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication
LM Schang
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2004)
From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-pliosphoinositide-dependent protein kinase-1 inhibitors (Publication with Expression of Concern. See vol. 79, pg. 1716, 2019)
JX Zhu et al.
CANCER RESEARCH (2004)
Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production
V Sanchez et al.
JOURNAL OF VIROLOGY (2004)
Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus
X Wang et al.
NATURE (2003)
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint
S Hauf et al.
JOURNAL OF CELL BIOLOGY (2003)
Influenza-virus-induced signaling cascades: targets for antiviral therapy?
S Ludwig et al.
TRENDS IN MOLECULAR MEDICINE (2003)
Cyclin-dependent kinases as cellular targets for antiviral drugs
LM Schang
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2002)
Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type I by targeting cellular, not viral, proteins
LM Schang et al.
JOURNAL OF VIROLOGY (2002)
MEK-specific inhibitor U0126 blocks spread of Borna disease virus in cultured cells
O Planz et al.
JOURNAL OF VIROLOGY (2001)
Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade
S Pleschka et al.
NATURE CELL BIOLOGY (2001)
BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells
M Egeblad et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Entry of influenza viruses into cells is inhibited by a highly specific protein kinase C inhibitor
CN Root et al.
JOURNAL OF GENERAL VIROLOGY (2000)
Flavopiridol inhibits P-TEFb and blocks HIV-1 replication
SH Chao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Cyclin-dependent kinases inhibitors as potential anticancer, antineurodegenerative, antiviral and antiparasitic agents
L Meijer
DRUG RESISTANCE UPDATES (2000)
Share Paper
