Journal
JOURNAL OF MATERIALS SCIENCE
Volume 56, Issue 15, Pages 9434-9444Publisher
SPRINGER
DOI: 10.1007/s10853-021-05828-y
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Funding
- National Natural Science Foundation of China [21703255]
- Natural Science Foundation of Anhui Province [1908085MB47, 1708085MB35]
- Key Projects of Anhui Province University Outstanding Youth Talent Support Program [gxyqZD2018021]
- Research Fund for the Doctoral Program of Anhui Medical University [XJ201808]
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The study developed vancomycin-encapsulated ZIF-8 nanoparticles with the ability to combat gram-positive bacteria. These nanoparticles, prepared by a simple method, exhibit higher antibacterial efficacy than free vancomycin molecules and show strong photoinactivation of bacteria under light irradiation.
In recent years, antibiotic-conjugated nanoparticles have attracted great interest for use as antimicrobial agents. Unfortunately, most of antibiotic-conjugated nanocomposites are involved in a multi-step and time-consuming process. Herein, we developed a vancomycin-encapsulated ZIF-8 (VAN@ZIF-8) nanoparticles by a simple one-pot approach to combat bacteria. The prepared VAN@ZIF-8 nanoparticles have the capacity to recognize gram-positive bacteria because of the strong and specific five-hydrogen bond between the VAN and the D-alanyl-D-alanine dipeptide coming from gram-positive bacteria cell wall. Importantly, owing to the multivalent nanoparticle-bacterium interactions, the VAN-encapsulated ZIF-8 nanoparticles exhibit a higher antibacterial efficacy in gram-positive bacteria compared to the free VAN molecules. In addition, the VAN@ZIF-8 nanoparticles as photocatalysts also show a strong photoinactivation of the bacteria under light irradiation. The present study is of interest for opening up tremendous opportunities to make good use of ZIF-8 and other MOFs in applications to combat bacteria, because of their excellent antibacterial activity and facile preparation method. [GRAPHICS] .
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