Journal
JOURNAL OF LIPOSOME RESEARCH
Volume 31, Issue 3, Pages 279-290Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08982104.2020.1806873
Keywords
Chimeric liposomes; light scattering; thermoresponsive copolymer; pH-responsive copolymer
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The study aims to prepare stimuli-responsive chimeric liposomes containing functional copolymers and conduct aqueous solution studies to determine their self-assembly properties and potential as drug delivery carriers. This involved synthesizing copolymers, preparing chimeric liposomes, and loading drugs to investigate their properties in aqueous solutions.
The purpose of this study is to prepare stimuli-responsive chimeric liposomes (i.e. hybrid polymer-lipid liposomes) containing functional copolymers and conduct aqueous solution studies in order to determine their properties and potential as drug-delivery nanocarriers. Two random copolymers, composed of the hydrophilic, pH and thermo-responsive 2-(dimethyl amino) ethyl methacrylate (DMAEMA) monomer and the hydrophobic stearyl methacrylate (SMA) monomer, were synthesized via free-radical polymerization and molecularly characterized using SEC, FTIR, and 1H-NMR. The synthesis was followed by aqueous solution studies, utilising dynamic light scattering (DLS) in order to determine their stimuli responsive self-assembly properties. The preparation of chimeric liposomes was mediated by thin film deposition and hydration, followed by aqueous solution studies via DLS, zeta-potential and fluorescence spectroscopy. The drug-loading studies include curcumin loading via a thin film deposition and hydration technique, while aqueous solution properties of the drug-loaded chimeric liposomes were determined utilizing DLS, and UV-Vis spectroscopy.
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