Journal
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Volume 64, Issue 6, Pages 237-242Publisher
WILEY
DOI: 10.1002/jlcr.3907
Keywords
[C-11]CO2; [C-11]propiolic acid; alkynes; carbon‐ 11; catalysed carboxylation
Funding
- Department of Health
- Wellcome/EPSRC Centre for Medical Engineering [WT 203148/Z/16/Z]
- Medical Research Council [MR/K022733/1]
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A copper-catalysed radiosynthesis was developed to obtain carbon-11-labelled carboxylic acids by reacting terminal alkynes with cyclotron-produced carbon-11 carbon dioxide in the presence of DBU. This method resulted in a small library of C-11-labelled propiolic acid derivatives with radiochemical yields ranging from 7% to 28% in a total synthesis time of 15 min from end of bombardment (EOB).
A copper-catalysed radiosynthesis of carbon-11 radiolabelled carboxylic acids was developed by reacting terminal alkynes and cyclotron-produced carbon-11 carbon dioxide ([C-11]CO2) in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). A small library of C-11-labelled propiolic acid derivatives were obtained with a total synthesis time of 15 min from end of bombardment (EOB) with a (non-isolated) radiochemical yield ranging from 7% to 28%.
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