Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 141, Issue 3, Pages 479-480Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2020.08.006
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Recent research has found that cancer-associated fibroblasts (CAFs) are abundant in mycosis fungoides (MF), promoting the motility and chemoresistance of malignant T cells. Targeting CAFs in MF may have therapeutic potential.
Research in cutaneous T-cell lymphoma has widened from the malignant T cell itself to the tumor microenvironment. In this issue of the Journal of Investigative Dermatology, Aronovich et al. (2020) report the presence of cancer-associated fibroblasts (CAFs) in mycosis fungoides (MFs). They show that CAFs are abundant in early-stage MF and that they differ from normal fibroblasts. Moreover, CAFs are described to promote MF by increasing the motility and chemoresistance of malignant T cells. Thus, targeting CAFs in MF may be of therapeutic value.
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