Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 223, Issue -, Pages S1-S3Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiaa738
Keywords
HIV cure; viral remission; shock and kill; immune response
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Funding
- Harvard University Center for AIDS Research (National Institute of Allergy and Infectious Diseases) [5P30AI060354]
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This article discusses the progress in understanding HIV persistence mechanisms and the challenges in achieving treatment goals. The supplement provides a review of technical hurdles, key assays, and next-generation therapeutic approaches for HIV remission.
Since the first case of an HIV sterilizing cure was published, remarkable progress has been made in our understanding of the mechanisms behind HIV persistence. However, our goal of achieving a safe and broadly-available treatment for sustained HIV remission has proven elusive. In this supplement, we provide a series of articles reviewing the technical hurdles facing the field, key assays to measure HIV persistence and the next-generation of therapeutics for HIV remission.
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