Long-Term Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infectiousness Among Three Immunocompromised Patients: From Prolonged Viral Shedding to SARS-CoV-2 Superinfection

Letter Immunology

Asymptomatic Reinfection in 2 Healthcare Workers From India With Genetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2

Vivek Gupta et al.

CLINICAL INFECTIOUS DISEASES (2021)

Article Immunology

Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient

Ji Hoon Baang et al.

Summary: This case illustrates challenges in managing immunocompromised hosts with chronic COVID-19, who may act as persistent shedders and sources of transmission. The patient's lack of seroconversion and prolonged course highlight the importance of humoral immunity in resolving viral infections.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Infectious Diseases

Genomic evidence for reinfection with SARS-CoV-2: a case study

Richard L. Tillett et al.

Summary: A man was infected with SARS-CoV-2 twice with genetically different virus variants, the second infection being more severe. The study suggests that previous exposure to SARS-CoV-2 may not guarantee immunity, and all individuals should take precautions to avoid infection. This has implications for vaccine development and application.

LANCET INFECTIOUS DISEASES (2021)

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Article Multidisciplinary Sciences

Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)

Jeroen J. A. van Kampen et al.

Summary: The study found that the median duration of shedding infectious virus in COVID-19 patients is 8 days, dropping below 5% after 15.2 days post onset of symptoms. High viral loads are associated with infectious SARS-CoV-2 isolation, while high serum neutralizing antibody titres are associated with non-infectious SARS-CoV-2.

NATURE COMMUNICATIONS (2021)

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Article Surgery