Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 224, Issue 6, Pages 983-988Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiab127
Keywords
SARS-CoV-2; antibodies; sex-related differences; COVID-19
Categories
Funding
- Strasbourg University Hospitals (Hopitaux Universitaires de Strasbourg) [PRI 7782]
- Agence Nationale de la Recherche [ANR-18-CE17-0028]
- Laboratoire d'Excellence TRANSPLANTEX [ANR-11-LABX-0070_TRANSPLANTEX]
- Institut National de la Sante et de la Recherche Medicale [UMR_S 1109]
- Institut Pasteur, Urgence COVID-19 Fundraising Campaign of Institut Pasteur
- Agence Nationale de recherches sur le sida, Sidaction
- Vaccine Research Institute [ANR-10-LABX-77]
- Labex IBEID [ANR-10-LABX-62-IBEID]
- TIMTAMDEN Agence Nationale de la Recherche [ANR-14-CE14-0029]
- CHIKV-Viro-Immuno [ANR-14-CE14-0015-01]
- Gilead HIV cure program
- ANR/Fondation Pour la Recherche Medicale Flash COVID
- French Ministry of Higher Education, Research and Innovation
- Agence Nationale de la Recherche (ANR) [ANR-14-CE14-0015] Funding Source: Agence Nationale de la Recherche (ANR)
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In a study of 308 healthcare workers with mild COVID-19, it was found that individuals over 50 years old and with a BMI over 25 kg/m(2) had higher levels of anti-S and anti-N antibodies in the first month. Between months 3-6, 99% of individuals had detectable anti-S antibodies, while 59% had anti-N antibodies. Additionally, anti-S and neutralizing antibodies declined faster in men compared to women, regardless of age and BMI.
We measured anti-spike (S), nucleoprotein (N), and neutralizing antibodies in sera from 308 healthcare workers with a positive reverse-transcription quantitative polymerase chain reaction result for severe acute respiratory syndrome coronavirus 2 and with mild disease, collected at 2 timepoints up to 6 months after symptom onset. At month 1, anti-S and -N antibody levels were higher in male participants aged >50 years and participants with a body mass index (BMI) >25 kg/m(2). At months 3-6, anti-S and anti-N antibodies were detected in 99% and 59% of individuals, respectively. Anti-S antibodies and neutralizing antibodies declined faster in men than in women, independent of age and BMI, suggesting an association of sex with evolution of the humoral response.
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