Journal
JOURNAL OF HOSPITAL INFECTION
Volume 111, Issue -, Pages 180-183Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.jhin.2021.01.031
Keywords
Coronavirus; SARS-CoV-2; Mouthwash; Octenidine dihydrochloride; Antiviral
Funding
- Schulke & Mayr GmbH, Norderstedt, Germany
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The outbreak of the SARS-CoV-2 pandemic has led to a global health emergency alert, requiring urgent effective preventive measures. Recent research has emphasized the relevance of aerosols in the spread of SARS-CoV-2. An investigation of commercially available antiseptic mouthwashes based on OCT has shown effectiveness against SARS-CoV-2, making it a potential candidate for future clinical studies on prevention of transmission.
The outbreak of the SARS-CoV-2 pandemic is triggering a global health emergency alert. Until vaccination becomes available, a bundle of effective preventive measures is desperately needed. Recent research is indicating the relevance of aerosols in the spread of SARS-CoV-2. Thus, in this study commercially available antiseptic mouthwashes based on the active ingredients chlorhexidine digluconate and octenidine dihydrochloride (OCT) were investigated regarding their efficacy against SARS-CoV-2 using the European Standard 14476. Based on the requirement of EN 14476 in which reduction of at least four decimal logarithms (>= 4 log(10)) of viral titre is requested to state efficacy, the OCT-based formulation was found to be effective within a contact time of only 15 s against SARS-CoV-2. Based on this in-vitro data the OCT mouthwash thus constitutes an interesting candidate for future clinical studies to prove its effectiveness in a potential prevention of SARS-CoV-2 transmission by aerosols. (C) 2021 The Authors. Published by Elsevier Ltd on behalf of The Healthcare Infection Society.
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