Journal
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
Volume 96, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jfca.2020.103726
Keywords
Momordica charantia (bitter gourd); Triterpenoids; Triterpenes; Saponins; Chemical characteristics; Pharmacological activities
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Funding
- National Natural Science Foundation of China [81673663, 81973217]
- Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2018RC350014]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-3-015]
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Bitter gourd is a world-famous medical vegetable with various pharmacological activities, including lipid- and glucose-lowering effects. It is rich in triterpenes and saponins, showing promising biological effects such as anti-diabetic, anti-tumor, anti-bacterial, anti-viral, and anti-inflammatory activities. Studies suggest that triterpenoids in bitter gourd could play a key role in mediating diverse biological effects and have the potential to be developed into new drugs.
The bitter gourd (Momordica charantia L.) is a world-famous medical vegetable involved in multiple pharmacological activities especially known for its lipid- and glucose-lowering effects. As a result of its abundance of triterpenes and saponins (collectively called triterpenoids), growing evidence shows that they have a variety of biological effects, including anti-diabetic, anti-tumor, anti-bacterial, anti-viral, and anti-inflammatory activities. These studies indicate that triterpenoids (triterpenes) which are thought to play a key role in mediating diverse biological effects are likely to be underestimated in bitter gourd. To date, there is no comprehensive review specifying the composition and pharmacological activities of triterpenoids in this medical food. In this review, we focused on the structural diversity and biological function of M. charantia-derived triterpenes and saponins for the first time. The summarized information emphasizes the chemical complexity and promising clinical utility of M. charantia-derived triterpenoids which deserve more effort to be isolated, chemically characterized, functionally clarified, and eventually should be developed as new drugs or adjuvant treatment.
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