4.6 Article

Digging deeper into the mother-offspring transfer of selenium through human breast milk

Journal

JOURNAL OF FOOD COMPOSITION AND ANALYSIS
Volume 99, Issue -, Pages -

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jfca.2021.103870

Keywords

Breast milk; Selenoprotein P; Inductively coupled plasma mass spectrometry; Food composition; Food analysis

Funding

  1. FEDER Andalusian operative program (Regional Ministry of Economy) [UHU-1256905]
  2. Spanish Ministry of Economy and Competi-tiveness (MINECO) [PGC2018-096608-B-C21]
  3. FEDER (European Community) [UNHU13-1E-1611, UNHU15-CE-3140]

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Selenoprotein P is found in human breast milk and plays a crucial role in selenium transfer during lactation. Concentration of selenium in maternal serum is higher than cord serum and breast milk, with glutathione peroxidase mainly transferred through breast milk.
Selenoprotein P contains most of the selenium in plasma and favours selenium retention in the brain over other organs. Recently, the presence of selenoprotein P in human breast milk has been demonstrated, filling the gap around the mother-offspring transfer of selenium during lactation and through cord serum. In this work, selenometabolites and selenoproteins have been accurately determined in human breast milk and cord and maternal sera. Using a heteroatom tagged proteomic method, twenty mother-child couples were analysed. The mean total concentration in maternal serum was 90 +/- 10 ng Se g(-1) (1.33 and 1.52-fold higher than that in cord serum and human breast milk, respectively). The concentration of selenoprotein P (ng Se g(-1)) follows the order: maternal serum (57.1 +/- 8.8) > cord serum (33.6 +/- 4.2) > breast milk (18.8 +/- 5.1). Glutathione peroxidase was mainly transferred by breast milk, selenometabolites were transferred by breast milk and cord serum and selenocystamine was only present in breast milk.

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