Journal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 40, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13046-021-01873-2
Keywords
Tumor microenvironment; Hepatocellular carcinoma; Tumor-associated macrophages; Immunotherapy; Immune checkpoint; Antitumor immunity
Categories
Funding
- National Natural Science Foundation of China [82073214]
- Outstanding disciplines leaders of Shanghai Municipal Commission of Health and Family Planning [2018BR39]
- Bethune Charitable Foundation
Ask authors/readers for more resources
In hepatocellular carcinoma patients, the tumor microenvironment characterized by high immunosuppression and drug resistance can be improved by remodeling the microenvironment and reprogramming the phenotype of tumor-associated macrophages to enhance the efficacy of immunotherapy.
In hepatocellular carcinoma patients, due to the microenvironmental specificity of liver, the tumor microenvironment exhibits high immunosuppression and drug resistance, resulting in excessive or insufficient responses to immunotherapy. The dynamic interactions between tumor cells and immune modulators in the TME significantly impact the occurrence and development of tumors, efficacy, and drug resistance, which can create a much more positive response to immunotherapy. Moreover, with the wide application of single-cell sequencing technology in the TME, increasing evidence shows an interaction network among cells. Sequencing results suggest that specific tumor-associated macrophages are a hub node, connecting different cell populations in the cell interaction network, and can could regulate tumor generation and antitumor immunity. This review focused on therapeutic targets that could be targeted to remodel the tumor microenvironment and reprogram the tumor-associated macrophage phenotype in hepatocellular carcinoma patients, thereby improving immunotherapeutic efficacy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available