Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 266, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2020.113399
Keywords
Antihypertensive; Calcium channel blockade; Coumarins; NO/cGMP system; Tagetes lucida; Vasorelaxant
Categories
Funding
- PAPIIT, DGAPA, U.N.A.M [INP3280A, CONACYT-80811, 226454, A1-S-13540, IN223519]
Ask authors/readers for more resources
The study on the extract of Tagetes lucida Cav. confirms its antihypertensive properties, mainly achieved through vasorelaxant effect by activating the NO/cGMP system and calcium channel blockade. Additionally, active compounds like 6,7,8-trimethoxycoumarin also significantly contribute to vasorelaxation.
Ethnopharmacological relevance: Tagetes lucida Cav. commonly known as yauhtli or peric ' on is used in Mexican traditional medicine for the treatment of anxiety, depressant diseases, pain, hypertension, among others. Aim: To evaluate the antihypertensive and vasorelaxant modes of action of a crude ethanolic extract from T. lucida aerial parts and to isolate the bioactive compounds. Materials and methods: Ethanolic extract was tested in an in vivo assay in SHR rats by intragastric administration at 10 and 100 mg/kg dosages, to measure and to compare hemodynamic parameters like diastolic and systolic blood pressure and heart rate. Also, extract (3.03-1000 mu g/ml), fractions (3.03-1000 mu g/ml) and pure isolated compounds (1.75-550 mu M) were evaluated on isolated aortic rings contracted with noradrenaline (0.1 mu M) to determine their vasorelaxant effect and extract-mode of action. Results: Ethanolic extract of T. lucida lowered systolic and diastolic blood pressure on SHR rats without heart rate modification (P 0.05). Moreover, the extract showed concentration-dependent relaxant effect in a partially endothelium-dependent manner (P < 0.05), through NO/cGMP system activation and calcium channel blockade. 6,7,8-trimethoxycoumarin (1), 6,7-dimethoxycoumarin (2), and 7-methoxycoumarin (3) from T. lucida are the main bioactive compounds of the extract and showed significant vasorelaxant activity. Conclusions: Results provide evidence and endorsed the antihypertensive properties attributed to T. lucida in traditional medicine, which is produced by vasorelaxant effect mainly through multitarget NO/cGMP system activation and calcium channel blockade. Coumarin derivatives 1, 2 and 3 are the responsible of the vasorelaxant activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available